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Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression.
Gene Name: | BTB (POZ) Domain Containing 7 |
Synonyms: | BTBD7, BTB (POZ) domain containing 7, FUP1, KIAA1525 |
Target Sequences: | AK001510 BAA91730.1 Q9P203 |
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