BST2

bone marrow stromal cell antigen 2

IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities. Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu. Isoform 1 acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2.

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Products

Proteins (11)

Type

Over-Expression Lysate (2)

Recombinant (9)

Target

BST2 (11)

Publications

No (11)

Tag

6His, C-terminus (2)

Fc (1)

Fc, N-terminus (1)

GST (3)

His (1)

Myc-DDK (Flag) (3)

Species

Human (9)

Mouse (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (3)

Human Cells (2)

Mammalian Cells (1)

Wheat Germ Extract (3)

Purification

Purified (6)

Low Endotoxin Level

Low endotoxin level (4)

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Mouse BST2 Protein (Recombinant Fc, N-terminus) (Thr52-Asn151) - LS-G140769

Source:

HEK 293 Cells

Tag:

Fc, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

40 kDa

Price:

50 µg/$721

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Human BST2 Protein (Recombinant GST) (Full Length) - LS-G27658

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

45.54 kDa

Price:

10 µg/$479; 25 µg/$670

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Human BST2 Protein (Recombinant GST) (Full Length) - LS-G27659

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

41.25 kDa

Price:

10 µg/$479; 25 µg/$670

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Human BST2 Protein (Recombinant GST) (Full Length) - LS-G27660

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

46.2 kDa

Price:

10 µg/$479; 25 µg/$670

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Human BST2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74804

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.6 kDa

Price:

20 µg/$150

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Human BST2 Protein (Recombinant Fc) (Asn49-Ser160) - LS-G97195

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

41 kDa

Price:

50 µg/$721

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Human BST2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65088

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.6 kDa

Price:

20 µg/$1,107

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BST2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100263

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.6 kDa

Price:

100 µg/$494

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Human BST2 Protein (Recombinant His) - LS-G1338

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Human BST2 Protein (Recombinant 6His, C-terminus) (Asn49-Ser161) - LS-G139744

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

13.7 kDa

Price:

10 µg/$288; 50 µg/$436

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Human BST2 Protein (Recombinant 6His, C-terminus) (Asn49-Ser161) - LS-G39332

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

13.67kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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