BRSK2

BR serine/threonine kinase 2

Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

BRSK2 (4)

Publications

No (4)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human BRSK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88220

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.6 kDa

Price:

20 µg/$215

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Human BRSK2 Protein (Recombinant GST) (Full Length) - LS-G31436

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

44.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human BRSK2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70880

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.6 kDa

Price:

20 µg/$1,107

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BRSK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100185

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.6 kDa

Price:

100 µg/$710

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