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BRCC3 / BRCC36

BRCA1/BRCA2-containing complex, subunit 3

Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.

Gene Name: BRCA1/BRCA2-containing complex, subunit 3
Synonyms: BRCC3, C6.1A, BRCC36, BRISC complex subunit BRCC36, BRCA1-A complex subunit BRCC36, CXorf53, RP11-143H17.2
Target Sequences: NM_024332 NP_077308.1 P46736

☰ Filters
Products
Antibodies (39)
Primary (39)
BRCC3 / BRCC36 (39)
Human (39)
Mouse (11)
Rat (13)
Bat (6)
Bovine (3)
Gibbon (6)
Guinea pig (3)
Horse (6)
Monkey (6)
Orangutan (6)
Pig (6)
Rabbit (3)
Xenopus (3)
IHC (11)
IHC-P (10)
WB (38)
ELISA (9)
IF (2)
IP (2)
Peptide-ELISA (3)
rabbit (34)
mouse (5)
Product Group
IHCPlus (3)
IgG (17)
IgG1 (2)
IgG1,k (2)
monoclonal mc (4)
polyclonal pc (35)
AT3B1 (1)
OTI6G7 (2)
APC (1)
APC Conjugated (1)
Biotin Conjugated (5)
Carrier-free (1)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (2)
Unconjugated (19)
C-Terminus (8)
aa7-148 (8)
aa1-316 (2)
aa266-316 (2)
aa41-316 (2)
N-Terminus (1)
aa18-50 (1)
aa2-316 (1)
aa36-70 (1)
No (39)
BRCC3 / BRCC36 Antibody - Anti-BRCC3 / BRCC36 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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BRCC3 / BRCC36 Mouse anti-Human Monoclonal (AT3B1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
BRCC3 / BRCC36 Antibody - Anti-BRCC3 / BRCC36 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
BRCC3 / BRCC36 Antibody - Immunohistochemistry of paraffin-embedded human skeletal muscle using antibody at 1:100 dilution.
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal (aa1-316) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
BRCC3 / BRCC36 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal (aa2-316) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
BRCC3 / BRCC36 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
BRCC3 / BRCC36 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
BRCC3 / BRCC36 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
BRCC3 / BRCC36 Antibody - Detection of Human BRCC36 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-BRCC36 used at a dilution of 1:1000 (1 ug/ml).
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal (aa266-316) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
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BRCC3 / BRCC36 Mouse anti-Human Monoclonal (aa1-316) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$586
BRCC3 / BRCC36 Antibody - Western blot analysis of extracts of various cell lines.
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
BRCC3 / BRCC36 Antibody - Detection of Human BRCC36 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-BRCC36 used at a dilution of 1:250.
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal (aa266-316) Antibody
Human
IHC, IHC-P
Unconjugated
2.5 µg/$295; 100 µl/$532
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BRCC3 / BRCC36 Mouse anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
50 µg/$705
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC-P, WB
Unconjugated
0.1 mg/$434
BRCC3 / BRCC36 Antibody - All lanes: Anti-BRCC3 Antibody (N-Term) at 1:2000 dilution. Lane 1: MCF-7 whole cell lysate. Lane 2: 293T/17 whole cell lysate. Lane 3: human brain lysate. Lane 4: human heart lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 36 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal (aa18-50) Antibody
Human
Peptide-ELISA, WB
Unconjugated
200 µl/$393
BRCC3 / BRCC36 Antibody - All lanes: Anti-BRCC3 Antibody (N-Term) at 1:1000 dilution. Lane 1: human heart lysate. Lane 2: human brain lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 36 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal (aa36-70) Antibody
Human
Peptide-ELISA, WB
Unconjugated
200 µl/$393
BRCC3 / BRCC36 Antibody - Western blot analysis of BRCC3 using HepG2 whole lysates.
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
BRCC3 / BRCC36 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY BRCC3. (Right lane) cDNA for 48 hrs and lysed
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BRCC3 / BRCC36 Mouse anti-Human Monoclonal (aa41-316) (OTI6G7) Antibody
Human
WB
Unconjugated
100 µl/$434
BRCC3 / BRCC36 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY BRCC3. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BRCC3. (1:500)
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BRCC3 / BRCC36 Mouse anti-Human Monoclonal (aa41-316) (Carrier-free) (OTI6G7) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
BRCC3 / BRCC36 Antibody - BRCC3 / BRCC36 antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
BRCC3 / BRCC36 Antibody - BRCC3 / BRCC36 antibody Western blot of 435S Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
BRCC3 / BRCC36 Antibody - Western blot of BRCC3 / BRCC36 antibody.
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal (aa7-148) Antibody
Human
WB
Unconjugated
100 µl/$318; 200 µl/$364; 500 µl/$518; 1 ml/$595
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BRCC3 / BRCC36 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Rat, Human
WB
Biotin Conjugated
100 µl/$896
Select
BRCC3 / BRCC36 Rabbit anti-Human Polyclonal (FITC) Antibody
Mouse, Rat, Human
WB
FITC Conjugated
100 µl/$896
Select
BRCC3 / BRCC36 Rabbit anti-Human Polyclonal (PE) Antibody
Mouse, Rat, Human
WB
PE Conjugated
100 µl/$896
Viewing 1-25 of 39 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).