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Shirley, MA 01464
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BPIFA1 / SPLUNC1
BPI fold containing family A, member 1
Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression.
| Gene Name: | BPI fold containing family A, member 1 |
| Synonyms: | BPIFA1, BA49G10.5, Lung-specific protein X, LUNX, Ligand-binding protein RYA3, SPLUNC1, SPURT, Von Ebner protein Hl, LPLUNC3, NASG, PLUNC, Protein Plunc |
| Target Sequences: | NM_016583 NP_057667.1 Q9NP55 |
Publications (1)
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