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BOULE / BOLL

boule-like RNA-binding protein

BOULE / BOLL belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene Name: boule-like RNA-binding protein
Synonyms: BOLL, Bol, boule-like (Drosophila), Protein boule-like, BOULE
Target Sequences: Q8N9W6 Q8N9W6

Publications (1)

1
Interleukin-34, a Novel Paracrine/Autocrine Factor in Mouse Testis, and Its Possible Role in the Development of Spermatogonial Cells In Vitro. Alaa Sawaied, Eitan Lunenfeld, Mahmoud Huleihel. International journal of molecular sciences. 2020 October;21: [Full Text Article] [PubMed:33143373] [PMC:PMC7662511] Related Antibodies: LS-B7334.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).