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BMPR2

bone morphogenetic protein receptor, type II (serine/threonine kinase)

BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.

Gene Name: bone morphogenetic protein receptor, type II (serine/threonine kinase)
Family/Subfamily: Protein Kinase , Activin/TGFb
Synonyms: BMPR2, BMPR-II, BMPR-2, BMPR3, BMP type II receptor, BRK-3, PPH1, T-ALK, BMP type-2 receptor, BMR2
Target Sequences: NM_001204 NP_001195.2 Q13873

Publications (2)

1
Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors. Zhang Y, Mu Q, Zhou H, Vrijens K, Roussel MF, Jiang G, Yan B. Cell death & disease. 2012 3:e308. [PubMed:22573038] [PMC:PMC3366082] Related Antibodies: LS-C97662.
2
Estradiol Upregulates the Expression of the TGF-ß Receptors ALK5 and BMPR2 during the Gonadal Development of Schizothorax prenanti. Taiming Yan, Songpei Zhang, Yueping Cai, Zhijun Ma, Jiayang He, Qian Zhang, Faqiang Deng, Lijuan Ye, Hongjun Chen, Liang He, Jie Luo, Deying Yang, Zhi He. Animals: an open access journal from MDPI. 2021 May;11: [Full Text Article] [PubMed:34064919] [PMC:PMC8151950] Related Antibodies: LS-C178875.

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Proteins (10)
Over-Expression Lysate (2)
Recombinant (8)
BMPR2 (10)
No (10)
6His, C-terminus (2)
Fc/6His,C-terminus (1)
Fc-6His, C-terminus (1)
GST, N-terminus (1)
His-Fc (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (9)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Human Cells (3)
Mammalian Cells (2)
Wheat Germ Extract (1)
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Low endotoxin level (5)
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Human Cells
Fc-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.9kD
10 µg/$248; 50 µg/$321; 500 µg/$785; 1 mg/$1,021
BMPR2 Protein - Purified recombinant protein BMPR2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
112.2 kDa
20 µg/$1,107
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
15.05kD
10 µg/$248; 50 µg/$321; 500 µg/$1,262; 1 mg/$1,627
BMPR2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
BMPR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
115.2 kDa
20 µg/$150
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Human Cells
His-Fc
Less than 1.0 EU/µg protein (determined by LAL method).
42 kDa
200 µg/$1,148
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Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
15.1 kDa
10 µg/$248; 50 µg/$317
Select
Mammalian Cells
Fc/6His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.9 kDa
10 µg/$248; 50 µg/$317
BMPR2 Protein - Recombinant Bone Morphogenetic Protein Receptor 2 By SDS-PAGE
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E. coli
His-T7
17.7 kDa
10 µg/$287; 50 µg/$477; 100 µg/$762; 200 µg/$952; 1 mg/$2,083; 500 µg/$1,613; 5 mg/$3,333; 2 mg/$2,272
BMPR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
115.2 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).