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BMP8B

bone morphogenetic protein 8b

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.

Gene Name: bone morphogenetic protein 8b
Family/Subfamily: TGF beta , not assigned-TGF beta
Synonyms: BMP8B, BMP-8B, BMP-8, BMP8, Bone morphogenetic protein 8b, OP-2, Osteogenic protein 2, OP2
Target Sequences: NM_001720 NP_001711.2 P34820

Publications (1)

1
Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis. Bichen Zhang, Kalina Lapenta, Qi Wang, Jin Hyun Nam, Dongjun Chung, Marie E Robert, Michael H Nathanson, Xiaoyong Yang. The Journal of biological chemistry. 2021 June;297:100887. [Full Text Article] [PubMed:34146542] [PMC:PMC8267550] Related Antibodies: LS-C372895.

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Proteins (5)
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BMP8B (5)
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BMP8B Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
BMP8B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
44.6 kDa
20 µg/$150
BMP8B Protein - Recombinant  Bone Morphogenetic Protein 8B By SDS-PAGE
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E. coli
His-S
46.7 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
BMP8B Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
BMP8B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
44.6 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).