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BMP7

bone morphogenetic protein 7

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity.

Gene Name: bone morphogenetic protein 7
Family/Subfamily: TGF beta , not assigned-TGF beta
Synonyms: BMP7, Bone morphogenetic protein 7, Eptotermin alfa, OP-1, OP1, Osteogenic protein 1, BMP-7
Target Sequences: NM_001719 NP_001710.1 P18075

Publications (1)

1
BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-ß receptor type I ALK5. Bollum LK, Huse K, Oksvold MP, Bai B, Hilden VI, Forfang L, Yoon SO, Wälchli S, Smeland EB, Myklebust JH. PloS one. 2017 12:e0177188. (WB; Human) [Full Text Article] [PubMed:28489883] [PMC:PMC5425193] Related Antibodies: LS-C293046.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).