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BMP5

bone morphogenetic protein 5

BMP5 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.

Gene Name: bone morphogenetic protein 5
Family/Subfamily: TGF beta , not assigned-TGF beta
Synonyms: BMP5, BMP-5, Bone morphogenetic protein 5
Target Sequences: NM_021073 NP_066551.1 P22003

Publications (1)

1
IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury. Chen WY, Yang JL, Wu YH, Li LC, Li RF, Chang YT, Dai LH, Wang WC, Chang YJ. Experimental & molecular medicine. 2018 April;50:36. [Full Text Article] [PubMed:29674622] [PMC:PMC5938009]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).