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BMP4

bone morphogenetic protein 4

BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.

Gene Name: bone morphogenetic protein 4
Family/Subfamily: TGF beta , not assigned-TGF beta
Synonyms: BMP4, BMP-2B, BMP-4, BMP2B, BMP2B1, Bone morphogenetic protein 2B, Bone morphogenetic protein 4, DVR4, MCOPS6, OFC11, Zyme
Target Sequences: NM_001202 NP_001193.2 P12644

Publications (3)

1
Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration. Wertheimer T, Velardi E, Tsai J, Cooper K, Xiao S, Kloss CC, Ottmüller KJ, Mokhtari Z, Brede C, deRoos P, Kinsella S, Palikuqi B, Ginsberg M, Young LF, Kreines F, Lieberman SR, Lazrak A, Guo P, Malard F, Smith OM, Shono Y, Jenq RR, Hanash AM, Nolan DJ, Butler JM, Beilhack A, Manley NR, Rafii S, Dudakov JA, van den Brink MRM. Science immunology. 2018 January;3:pii: eaal2736. [Full Text Article] [PubMed:29330161] [PMC:PMC5795617]
2
Stimulation of Epithelial Sodium Channels in Endothelial Cells by Bone Morphogenetic Protein-4 Contributes to Salt-Sensitive Hypertension in Rats. Xu Yang, Na Niu, Chen Liang, Ming-Ming Wu, Liang-Liang Tang, Qiu-Shi Wang, Jie Lou, Bin-Lin Song, Wei-Wan Zheng, He-Ping Ma, Zhi-Ren Zhang. Oxidative medicine and cellular longevity. 2020 November;2020:3921897. [Full Text Article] [PubMed:33194000] [PMC:PMC7641672]
3
Potential Role of Circulating Endoglin in Hypertension via the Upregulated Expression of BMP4. Eunate Gallardo-Vara, Luis Gamella-Pozuelo, Lucía Perez-Roque, José L Bartha, Irene Garcia-Palmero, J Ignacio Casal, José M López-Novoa, Miguel Pericacho, Carmelo Bernabeu. Cells. 2020 Apr;9:988. [Full Text Article] [PubMed:32316263] [PMC:PMC7226995]

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BMP4 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$441
BMP4 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
2.74 - 2000 pg/ml
Chemiluminescent
Plasma, Serum, Tissue Homogenates
1 Plate/$968
BMP4 ELISA Kit
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Sandwich
96-Well Microplate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
BMP4 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Rat
13.72 - 10000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$1,034
BMP4 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$441
BMP4 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
BMP4 ELISA Kit
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Sandwich
96-Well Microplate
Human
15 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$588
BMP4 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Bone Tissue, Cell Culture Supernatants, Serum
1 Plate/$795
BMP4 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$958
BMP4 ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
BMP4 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
BMP4 ELISA Kit
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Development Kit
Antibody Pair and Standard
Human
5.48 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,124; 1000 Wells/$1,650
BMP4 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$764
BMP4 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.625 - 40 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$804
BMP4 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$441
BMP4 ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
BMP4 ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$783
BMP4 ELISA Kit
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Sandwich
96-Well Microplate
Rabbit
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$627
BMP4 ELISA Kit
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Sandwich
96-Well Microplate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
BMP4 ELISA Kit
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Sandwich
96-Well Microplate
Chicken
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$627
BMP4 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Bone Tissue Homogenates, Cell Culture Supernatants
1 Plate/$669
BMP4 ELISA Kit
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Sandwich
96-Well Microplate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$627
BMP4 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
BMP4 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
BMP4 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).