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BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5A1 and NDUFA9.
| Gene Name: | biogenesis of lysosomal organelles complex-1, subunit 1 |
| Synonyms: | BLOC1S1, BLOS1, BLOC-1 subunit 1, BLOC subunit 1, GCN5-like protein 1, GCN5L1, MICoA, MTA1-interacting coactivator, Protein RT14, RT14 |
| Target Sequences: | NM_001487 NP_001478.2 P78537 |
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