BLK

B lymphoid tyrosine kinase

Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.

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Products

Proteins (7)

Type

Recombinant (7)

Target

BLK (7)

Publications

No (7)

Tag

6His, C-terminus (2)

GST (2)

GST, N-terminus (1)

His (1)

His-T7 (1)

Species

Human (7)

Source

Baculovirus (1)

E. coli (4)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (3)

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Human BLK Protein (Recombinant GST) (Met1-Pro505) - LS-G97186

Source:

Baculovirus

Tag:

GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

84 kDa

Price:

50 µg/$707

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Human BLK Protein (Recombinant 6His, C-terminus) (Gly2-Pro505) - LS-G139498

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

58.7 kDa

Price:

10 µg/$376; 50 µg/$526

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Human BLK Protein (Recombinant His-T7) (aa241-494) - LS-G25452

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.7 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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Human BLK Protein (Recombinant GST) (Full Length) - LS-G27632

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

81.29 kDa

Price:

10 µg/$479; 25 µg/$670

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Human BLK Protein (Recombinant GST, N-terminus) (aa1-90) - LS-G57896

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human BLK Protein (Recombinant His) - LS-G1443

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Human BLK Protein (Recombinant 6His, C-terminus) (Gly2-Pro505) - LS-G39668

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

58.7kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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