BIRC8 / ILP2

baculoviral IAP repeat containing 8

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2. ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

BIRC8 / ILP2 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (2)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human BIRC8 / ILP2 Protein (Recombinant GST, N-terminus) (aa127-236) - LS-G63520

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human BIRC8 / ILP2 Protein (Recombinant GST, N-terminus) (aa1-236) - LS-G56867

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human BIRC8 / ILP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92823

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.9 kDa

Price:

20 µg/$150

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Human BIRC8 / ILP2 Protein (Recombinant GST) (Full Length) - LS-G36125

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

53.5 kDa

Price:

10 µg/$479; 25 µg/$670

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BIRC8 / ILP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108292

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.9 kDa

Price:

100 µg/$494

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