BIRC3 / cIAP2

baculoviral IAP repeat containing 3

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.

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Products

ELISA Kits (2)

Type

Sandwich (2)

Target

BIRC3 / cIAP2 (2)

Reactivity

Human (2)

Format

96-Well Microplate (1)

96-Well Strip Plate (1)

Publications

No (2)

Sample Type

Cell Culture Supernatants (1)

Plasma (2)

Serum (2)

Tissue Homogenates (1)

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Human BIRC3 / cIAP2 (Sandwich ELISA) ELISA Kit - LS-F56

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

1.024 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$840

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Human BIRC3 / cIAP2 (Sandwich ELISA) ELISA Kit - LS-F51527

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

37.5 - 2400 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$958

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