BIRC2 / cIAP1

baculoviral IAP repeat containing 2

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

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Products

Proteins (8)

Type

Over-Expression Lysate (3)

Recombinant (5)

Target

BIRC2 / cIAP1 (8)

Publications

No (8)

Tag

8His, N-terminus (1)

AVI (1)

GST (1)

His-GST, N-terminus (1)

His-S (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human BIRC2 / cIAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76762

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.7 kDa

Price:

20 µg/$150

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Human BIRC2 / cIAP1 Protein (Over-Expression Lysate 8His, N-terminus) (His2-Ser618) - LS-G26715

Source:

HEK 293 Cells

Tag:

8His, N-terminus

Molecular Weight:

71.4 kDa

Price:

100 µg/$298

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Human BIRC2 / cIAP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66020

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.7 kDa

Price:

20 µg/$1,107

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Human BIRC2 / cIAP1 Protein (Recombinant His-GST, N-terminus) (Phe344-Gln593) - LS-G15443

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

60.2 kDa

Price:

10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170

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Human BIRC2 / cIAP1 Protein (Recombinant GST) (Full Length) - LS-G27478

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

96.3 kDa

Price:

10 µg/$479; 25 µg/$670

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Human BIRC2 / cIAP1 Protein (Recombinant AVI) (Glu144-Leu356) - LS-G97311

Source:

E. coli

Tag:

AVI

Molecular Weight:

26.5 kDa

Price:

100 µg/$721

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BIRC2 / cIAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99353

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.7 kDa

Price:

100 µg/$494

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Human BIRC2 / cIAP1 Protein (Recombinant His-S) (aa148-298) - LS-G15438

Source:

E. coli

Tag:

His-S

Molecular Weight:

22.8 kDa

Price:

10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,505

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