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B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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BID
BH3 interacting domain death agonist
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bid, a pro-apoptotic Bcl-2 family member, is cleaved by caspase-8 in response to apoptotic signals, exposing the Bcl-2 homology 3 (BH3) domain which is normally buried in the full-length protein. The cleaved complex is myristoylated and translocated to the mitochondrial membrane where it may induce mitochondrial Bax and Bak to oligomerize.
| Gene Name: | BH3 interacting domain death agonist |
| Family/Subfamily: | Apoptosis |
| Synonyms: | BID, Apoptic death agonist, BID isoform L(2), BID isoform Si6, Bh3, FP497, p22 BID, BID isoform ES(1b), Desmocollin type 4, Human BID coding sequence |
| Target Sequences: | NM_001196 NP_001187.1 P55957 |
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