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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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BDNF

brain-derived neurotrophic factor

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

Gene Name: brain-derived neurotrophic factor
Family/Subfamily: NGF Beta , not assigned-NGF Beta
Synonyms: BDNF, ANON2, Abrineurin, BULN2, Neurotrophin
Target Sequences: NM_001709 NP_001700.2 P23560

Publications (4)

1
Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats. McCarthy CA, Vinh A, Miller AA, Hallberg A, Alterman M, Callaway JK, Widdop RE. PloS one. 2014 9:e95762. (Flo; Rat) [Full Text Article] [PubMed:24752645] [PMC:PMC3994132] Related Antibodies: LS-B3815.
2
Antidepressant-Like Effects of Acupuncture-Insights From DNA Methylation and Histone Modifications of Brain-Derived Neurotrophic Factor. Jiang H, Zhang X, Lu J, Meng H, Sun Y, Yang X, Zhao B, Bao T. Frontiers in psychiatry. 2018 March;9:102. (Human) [Full Text Article] [PubMed:29636708] [PMC:PMC5880910] Related Antibodies: LS-C343943.
3
TRKB tyrosine kinase receptor is a potential therapeutic target for poorly differentiated oral squamous cell carcinoma. Moriwaki K, Ayani Y, Kuwabara H, Terada T, Kawata R, Asahi M. Oncotarget. 2018 May;9:25225-25243. (Human) [Full Text Article] [PubMed:29861866] [PMC:PMC5982746]
4
Isorhynchophylline exerts antidepressant-like effects in mice via modulating neuroinflammation and neurotrophins: involvement of the PI3K/Akt/GSK-3ß signaling pathway. Xian YF, Ip SP, Li HQ, Qu C, Su ZR, Chen JN, Lin ZX. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 September;33:10393-10408. [Full Text Article] [PubMed:31233346]
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Viewing 1-25 of 81 items
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E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
27.0 kDa
2µg   $215.00; 10µg   $285.00
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2µg   $225.00; 10µg   $295.00
BDNF Protein - Recombinant Brain Derived Neurotrophic Factor By SDS-PAGE
Select
E. coli
His, N-Terminal
14.7 kDa
10µg   $305.00; 50µg   $545.00; 100µg   $740.00; 200µg   $1,080.00; 1mg   $2,805.00
BDNF Protein - Recombinant Brain Derived Neurotrophic Factor By SDS-PAGE
Select
E. coli
His
13.5 kDa
10µg   $325.00; 50µg   $620.00; 100µg   $845.00; 200µg   $1,230.00; 1mg   $3,150.00
BDNF Protein - Recombinant Brain Derived Neurotrophic Factor By SDS-PAGE
Select
E. coli
His
16.6 kDa
10µg   $295.00; 50µg   $495.00; 100µg   $695.00; 200µg   $1,005.00; 1mg   $2,580.00
Select
E. coli
None
Less than 0.1 ng/µg of protein (less than 1EU/µg).
~52 kDa
50µg   $755.00; 1mg   $5,985.00; 10µg   $345.00
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
27kD
10µg   $265.00; 50µg   $465.00; 500µg   $1,605.00; 1mg   $2,310.00
Select
E. coli
GST,N-terminus
47 kDa
200µg   $315.00
Select
E. coli
GST,N-terminus
40 kDa
200µg   $315.00
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc + DDK
27.85 kDa
20µg   $195.00
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
27.85 kDa
20µg   $195.00
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
31.12 kDa
20µg   $195.00
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
27.85 kDa
20µg   $195.00
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
27.85 kDa
20µg   $195.00
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
27.85 kDa
20µg   $195.00
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
27.85 kDa
20µg   $195.00
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
27.85 kDa
20µg   $195.00
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
25.7 kDa
20µg   $195.00
Select
293T Cells
Myc + DDK
25.7 kDa
20µg   $195.00
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
25.7 kDa
20µg   $195.00
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
25.7 kDa
20µg   $195.00
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
27.85 kDa
20µg   $195.00
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
27.85 kDa
20µg   $195.00
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
25.7 kDa
20µg   $195.00
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
27.82 kDa
20µg   $195.00

Viewing 1-25 of 81 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).