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BDNF

brain-derived neurotrophic factor

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

Gene Name: brain-derived neurotrophic factor
Family/Subfamily: NGF Beta , not assigned-NGF Beta
Synonyms: BDNF, ANON2, Abrineurin, BULN2, Neurotrophin
Target Sequences: NM_001709 NP_001700.2 P23560

Publications (4)

1
Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats. McCarthy CA, Vinh A, Miller AA, Hallberg A, Alterman M, Callaway JK, Widdop RE. PloS one. 2014 9:e95762. (Flo; Rat) [Full Text Article] [PubMed:24752645] [PMC:PMC3994132] Related Antibodies: LS-B3815.
2
Antidepressant-Like Effects of Acupuncture-Insights From DNA Methylation and Histone Modifications of Brain-Derived Neurotrophic Factor. Jiang H, Zhang X, Lu J, Meng H, Sun Y, Yang X, Zhao B, Bao T. Frontiers in psychiatry. 2018 March;9:102. (Human) [Full Text Article] [PubMed:29636708] [PMC:PMC5880910] Related Antibodies: LS-C343943.
3
TRKB tyrosine kinase receptor is a potential therapeutic target for poorly differentiated oral squamous cell carcinoma. Moriwaki K, Ayani Y, Kuwabara H, Terada T, Kawata R, Asahi M. Oncotarget. 2018 May;9:25225-25243. (Human) [Full Text Article] [PubMed:29861866] [PMC:PMC5982746]
4
Isorhynchophylline exerts antidepressant-like effects in mice via modulating neuroinflammation and neurotrophins: involvement of the PI3K/Akt/GSK-3ß signaling pathway. Xian YF, Ip SP, Li HQ, Qu C, Su ZR, Chen JN, Lin ZX. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 September;33:10393-10408. [Full Text Article] [PubMed:31233346]
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Antibodies (225)
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BDNF (225)
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rabbit (167)
mouse (39)
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BDNF Antibody - Anti-BDNF antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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Neuroscience
BDNF Goat anti-Human Polyclonal (aa183-194) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$440
BDNF Antibody - Mouse Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
BDNF Chicken anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$460
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BDNF Mouse anti-Human Monoclonal Antibody
Human
ELISA, Neut, WB
Unconjugated
100 µg/$771
BDNF Antibody - Anti-Human/Murine/Rat BDNF Western Blot Reduced
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BDNF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$325; 100 µg/$361
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BDNF Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$687
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BDNF Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$596
BDNF Antibody - BDNF antibody IHC-paraffin: Rat Brain Tissue.
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BDNF Rabbit anti-Human Polyclonal (aa129-247) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$421
BDNF Antibody - Immunohistochemistry of paraffin-embedded mouse brain using BDNF antibodyat dilution of 1:100 (40x lens).
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BDNF Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50 µl/$333; 100 µl/$429; 200 µl/$574
BDNF Antibody - Formalin-fixed and paraffin-embedded human brain reacted with BDNF Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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BDNF Rabbit anti-Human Polyclonal (aa206-236) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$381
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BDNF Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
500 µg/$548; 1 mg/$771
BDNF Antibody - Immunofluorescence of HeLa cells using BDNF mouse monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye. Secondary antibody from Fisher (Cat#: 35503)
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BDNF Mouse anti-Human Monoclonal (aa19-248) (3D9C5) Antibody
Human
ELISA, IF, WB
Unconjugated
0.1 mg/$426
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BDNF Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, IHC, WB
Unconjugated
100 µl/$614
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BDNF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$369
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BDNF Mouse anti-Human Monoclonal (aa19-247) (TS106) Antibody
Mouse, Human
IHC, WB
Unconjugated
100 µg/$787
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BDNF Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$284; 100 µg/$348
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BDNF Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$284; 100 µg/$348
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BDNF Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
50 µg/$284; 100 µg/$348
BDNF Antibody - Western blot of extracts of SH-SY5Y cell and PC-12 cell lines, using BDNF antibody.
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BDNF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µl/$433
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BDNF Sheep anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
500 µg/$614
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BDNF Sheep anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µg/$369
BDNF Antibody - Anti-BDNF Antibody. Lane A: K562 Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 27 kDa. Observed band size: 27 kDa.
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BDNF Rabbit anti-Mouse Monoclonal (Preservative Free) (010) Antibody
Mouse
ELISA, WB
Unconjugated, Preservative Free
50 µl/$290; 100 µl/$350
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BDNF Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$788
BDNF Antibody
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BDNF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µl/$317
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BDNF Chicken anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
500 µg/$570
BDNF Antibody - 1:100 staining human brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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BDNF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).