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BDNF

brain-derived neurotrophic factor

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

Gene Name: brain-derived neurotrophic factor
Family/Subfamily: NGF Beta , not assigned-NGF Beta
Synonyms: BDNF, ANON2, Abrineurin, BULN2, Neurotrophin
Target Sequences: NM_001709 NP_001700.2 P23560

Publications (8)

1
Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats. McCarthy CA, Vinh A, Miller AA, Hallberg A, Alterman M, Callaway JK, Widdop RE. PloS one. 2014 9:e95762. (Flo; Rat) [Full Text Article] [PubMed:24752645] [PMC:PMC3994132] Related Antibodies: LS-B3815.
2
Antidepressant-Like Effects of Acupuncture-Insights From DNA Methylation and Histone Modifications of Brain-Derived Neurotrophic Factor. Jiang H, Zhang X, Lu J, Meng H, Sun Y, Yang X, Zhao B, Bao T. Frontiers in psychiatry. 2018 March;9:102. (Human) [Full Text Article] [PubMed:29636708] [PMC:PMC5880910] Related Antibodies: LS-C343943.
3
TRKB tyrosine kinase receptor is a potential therapeutic target for poorly differentiated oral squamous cell carcinoma. Moriwaki K, Ayani Y, Kuwabara H, Terada T, Kawata R, Asahi M. Oncotarget. 2018 May;9:25225-25243. (Human) [Full Text Article] [PubMed:29861866] [PMC:PMC5982746]
4
Isorhynchophylline exerts antidepressant-like effects in mice via modulating neuroinflammation and neurotrophins: involvement of the PI3K/Akt/GSK-3ß signaling pathway. Xian YF, Ip SP, Li HQ, Qu C, Su ZR, Chen JN, Lin ZX. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 September;33:10393-10408. [Full Text Article] [PubMed:31233346]
5
Intracerebral Transplantation of Neural Stem Cells Restores Manganese-Induced Cognitive Deficits in Mice. Huijuan Shu , Zhongxin Guo , Xiangren Chen , Shuya Qi , Xinxin Xiong , Shuang Xia , Qingyun Huang , Ling Lan , Jiangu Gong , Shaoming Huang , Boning Yang , Guohe Tan. Aging and Disease. 2021 Apr;12:371-385. [Full Text Article] [PubMed:33815871] [PMC:PMC7990353] Related Antibodies: LS-C196746.
6
Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Kumarpillai Gopukumar, Shefali Thanawala, Venkateswarlu Somepalli, T S Sathyanaryana Rao, Vijaya Bhaskar Thamatam, Sanjaya Chauhan. Evidence-based complementary and alternative medicine : eCAM. 2021 December;2021:8254344. [Full Text Article] [PubMed:34858513] [PMC:PMC8632422]
7
Impact of Berberine on Some Epigenetic, Transcription Regulation and Inflammatory Biomarkers in a Mice Model of Epilepsy. Heba Bassiony Ghanem, Marwa Nagy Emam, Ali Dareen Abdelaziz Mohammed, Abd-Ellatif Rania Nagi. Reports of biochemistry & molecular biology. 2021 October;10:362-372. [Full Text Article] [PubMed:34981012] [PMC:PMC8718772]
8
BDNF/TRKB axis provokes EMT progression to induce cell aggressiveness via crosstalk with cancer-associated fibroblasts in human parotid gland cancer. Kazumasa Moriwaki , Masaki Wada , Hiroko Kuwabara, Yusuke Ayani, Tetsuya Terada, Masaaki Higashino, Ryo Kawata, Michio Asahi. Scientific reports. 2022 October;12:17553. [Full Text Article] [PubMed:36266462] [PMC:PMC9584965]
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Proteins (64)
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BDNF (64)
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His (7)
His, N-Terminal (8)
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BDNF Protein - Eukaryotic Brain Derived Neurotrophic Factor (BDNF) by SDS-PAGE
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293F Cells
His, N-Terminal
25kDa
10 µg/$482; 50 µg/$1,156; 200 µg/$1,876; 100 µg/$1,623; 1 mg/$3,841; 500 µg/$2,728; 5 mg/$9,601
BDNF Protein - Recombinant Brain Derived Neurotrophic Factor By SDS-PAGE
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E. coli
His, N-Terminal
16.6 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
BDNF Protein - Recombinant Brain Derived Neurotrophic Factor By SDS-PAGE
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E. coli
His
13.5 kDa
10 µg/$304; 50 µg/$587; 100 µg/$940; 200 µg/$1,133; 1 mg/$2,340; 500 µg/$1,848; 5 mg/$4,103; 2 mg/$2,532
BDNF Protein - Recombinant Brain Derived Neurotrophic Factor By SDS-PAGE
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E. coli
His, N-Terminal
14.7 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
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E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
27.0 kDa
2 µg/$268; 10 µg/$349
BDNF Protein - Recombinant Brain Derived Neurotrophic Factor By SDS-PAGE
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E. coli
His-GST
45.0 kDa
50 µg/$482; 10 µg/$287; 200 µg/$962; 100 µg/$770; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
BDNF Protein - Purified recombinant protein BDNF was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
25.7 kDa
20 µg/$1,107
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
27.85 kDa
20 µg/$150
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
27.85 kDa
20 µg/$150
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
27.85 kDa
20 µg/$150
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
31.12 kDa
20 µg/$150
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
27.85 kDa
20 µg/$150
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
27.85 kDa
20 µg/$150
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
27.85 kDa
20 µg/$150
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
27.85 kDa
20 µg/$150
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
27.85 kDa
20 µg/$150
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
27.85 kDa
20 µg/$150
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
27.82 kDa
20 µg/$150
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
25.7 kDa
20 µg/$150
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
25.7 kDa
20 µg/$150
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
25.7 kDa
20 µg/$150
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
25.7 kDa
20 µg/$150
BDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
25.7 kDa
20 µg/$150
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HEK 293 Cells
His, N-Terminal
~13 kDa
200 µl/$283
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HEK 293 Cells
His, N-Terminal
~28 kDa
100 µg/$298
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).