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BCL7A

B-cell CLL/lymphoma 7A

BCL7A is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: B-cell CLL/lymphoma 7A
Family/Subfamily: Cancer
Synonyms: BCL7A, B-cell CLL/lymphoma 7A, BCL7, B-cell CLL/lymphoma-7
Target Sequences: NM_020993 NP_066273.1 Q4VC05

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).