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BCL2L2 / Bcl-w
BCL2-like 2
BCL2L2 / Bcl-w is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
| Gene Name: | BCL2-like 2 |
| Family/Subfamily: | Apoptosis |
| Synonyms: | BCL2L2, BCLW, BCL2-L-2, KIAA0271, PPP1R51, Apoptosis regulator Bcl-W, Bcl-2-like protein 2, BCL-W, BCL2-like 2 |
| Target Sequences: | NM_004050 NP_004041.1 Q92843 |
Publications (2)
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