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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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BCL2L11 / BIM

BCL2-like 11 (apoptosis facilitator)

BCL2L11 / BIM belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

Gene Name: BCL2-like 11 (apoptosis facilitator)
Family/Subfamily: Apoptosis
Synonyms: BCL2L11, BIM-alpha6, BIM-beta7, Bcl-2-like protein 11, BIM-beta6, BimL, BimS, Bcl-2 interacting protein Bim, BimEL, BAM, Bcl2-L-11, BIM, BOD
Target Sequences: NM_006538 O43521 O43521

Filtered by: None
Target
BCL2L11 / BIM (127)
Reactivity
Human (124)
Mouse (74)
Rat (70)
Bovine (2)
Dog (4)
Hamster (1)
Horse (1)
Monkey (9)
Pig (2)
Rabbit (1)
Sheep (1)
Application
IHC (64)
IHC-P (11)
WB (110)
Flo (15)
ELISA (42)
ICC (30)
IF (12)
IP (8)
Peptide-ELISA (3)
Host
rabbit (107)
mouse (11)
goat (2)
hamster (2)
rat (5)
Isotype
IgG (53)
IgG1 (5)
IgG1,k (7)
IgG2a (2)
IgG2a,k (2)
IgG2b (1)
Clonality
monoclonal mc (20)
polyclonal pc (107)
Clone
10B12 (1)
1C2C8 (1)
1C2H4 (1)
3C5 (1)
G1/G1-4 (1)
Ham151-149 (1)
OTI2H5 (2)
Format
AP Conjugated (6)
APC (1)
APC Conjugated (6)
Atto 390 Conjugated (2)
Atto 488 Conjugated (2)
Atto 565 Conjugated (2)
Atto 594 Conjugated (4)
Atto 633 Conjugated (2)
Atto 655 Conjugated (2)
Atto 680 Conjugated (2)
Atto 700 Conjugated (2)
Azide-free (2)
Biotin Conjugated (10)
Carrier-free (1)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (8)
HRP Conjugated (6)
PE (2)
PE Conjugated (5)
PerCP Conjugated (2)
Preservative Free (4)
RPE Conjugated (2)
SA Conjugated (2)
Unconjugated (60)
Epitope
Internal (34)
aa130-165 (8)
aa134-160 (8)
aa2-120 (8)
aa22-40 (4)
aa20-40 (3)
pSer69 (3)
N-Terminus (2)
aa1-198 (2)
pSer65 (2)
1-80 aa (1)
1-80 aa, N-terminal (1)
Ala2 (1)
C-Terminus (1)
Ser69 (1)
aa1-100 (1)
aa1-50 (1)
aa159-169 (1)
pSer59 (1)
pSer69/65 (1)
pSer77 (1)
Publications
No (127)
Showing 1-25 of 127 results

IHC-plus™ BCL2L11 / BIM Antibody LS-B1337
Rabbit Polyclonal (IgG) to Human BCL2L11 / BIM
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50µg 1mg/ml  $545.00
Anti-BCL2L11 / BIM antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-BCL2L11 / BIM antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

BCL2L11 / BIM Antibody (N-Terminus) LS-C35140
Rabbit Polyclonal to Human BCL2L11 / BIM
Human, Monkey
ELISA, Flo, IF, IP, WB
Unconjugated
100µl  $530.00

IHC-plus™ BCL2L11 / BIM Antibody (aa134-160) LS-B10712
Rabbit Polyclonal to Human BCL2L11 / BIM
Human
Flo, IHC, IHC-P, WB
Unconjugated
200µl  $425.00
Anti-BCL2L11 / BIM antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Western blot of BCL2L11 Antibody in K562, HL-60 cell line lysates (35 ug/lane). BCL2L11 (arrow) was detected using the purified antibody.

BCL2L11 / BIM Antibody (aa1-50) LS-C118395
Rabbit Polyclonal (IgG) to Human BCL2L11 / BIM
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using BIM Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from COS7 cells, using BIM Antibody. The lane on the right is blocked with the synthesized peptide.

BCL2L11 / BIM Antibody (clone 1C2C8) LS-C53498
Mouse Monoclonal [clone 1C2C8] (IgG1) to Human BCL2L11 / BIM
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50µg 1mg/ml  $365.00
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunocytochemistry of Bim in K562 cells with Bim antibody at 10 ug/ml.

BCL2L11 / BIM Antibody (phospho-Ser69) LS-C354571
Rabbit Polyclonal to Human BCL2L11 / BIM
Mouse, Sheep, Bovine, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $265.00
Immunohistochemical analysis of BIM (pS69) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX. w
Immunofluorescent analysis of BIM (pS69) staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

BCL2L11 / BIM Antibody LS-C292
Rabbit Polyclonal (IgG) to Human BCL2L11 / BIM
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1mg  $365.00
Immunohistochemistry of Bim in human skin cancer cells with Bim antibody at 20 µg/ml.
Immunofluorescence of Bim in K562 cells with Bim Antibody at 20 µg/mL.

BCL2L11 / BIM Antibody (aa134-160) LS-C326923
Rabbit Polyclonal (IgG) to Human BCL2L11 / BIM
Human
ELISA, Flo, IHC, WB
Unconjugated
200µl  $590.00

BCL2L11 / BIM Antibody (aa134-160, FITC) LS-C275472
Rabbit Polyclonal (IgG) to Human BCL2L11 / BIM
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200µl  $740.00

BCL2L11 / BIM Antibody (Preservative Free) LS-C343367
Rabbit Monoclonal (IgG) to Human BCL2L11 / BIM
Human
ELISA, IP, WB
Unconjugated, Preservative Free
20µg  $195.00; 100µg  $265.00; 200µg  $295.00; 500µg  $415.00

BCL2L11 / BIM Antibody (Preservative Free, Biotin) LS-C343261
Rabbit Monoclonal (IgG) to Human BCL2L11 / BIM
Human
ELISA, IP, WB
Biotin Conjugated, Preservative Free
50µg  $295.00

BCL2L11 / BIM Antibody (Internal, Biotin) LS-C229513
Rabbit Polyclonal to Human BCL2L11 / BIM
Mouse, Rat, Human
IHC, WB
Biotin Conjugated
100µg 1mg/ml  $375.00
Western blot analysis of Bim in K562 (Left) and A549 (Right) whole cell lysates using a 1:1000 dilution of BCL2L11 / BIM antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

BCL2L11 / BIM Antibody (aa20-40) LS-C4155
Rat Monoclonal (IgG2a) to Mouse BCL2L11 / BIM
Mouse, Hamster, Pig, Human, Monkey
ELISA, Flo, ICC, IHC, IP, WB
Unconjugated
100µg  $680.00

BCL2L11 / BIM Antibody (Preservative Free, Biotin) LS-C343563
Rabbit Polyclonal (IgG) to Human BCL2L11 / BIM
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50µg  $295.00

BCL2L11 / BIM Antibody (aa159-169) LS-C54579
Goat Polyclonal to Human BCL2L11 / BIM
Human
Peptide-ELISA, WB
Unconjugated
100µg 0.5mg/ml  $405.00
Antibody staining (0.5 ug/ml) of K562lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.

BCL2L11 / BIM Antibody (aa1-100) LS-C306553
Mouse Monoclonal (IgG1,k) to Human BCL2L11 / BIM
Human
ELISA
Unconjugated
100µg  $560.00

BCL2L11 / BIM Antibody (Biotin) LS-C520962
Mouse Monoclonal (IgG1,k) to Human BCL2L11 / BIM
Human
ELISA
Biotin Conjugated
100µl  $710.00

BCL2L11 / BIM Antibody (aa20-40, clone 10B12) LS-C344803
Rat Monoclonal [clone 10B12] (IgG2a,k) to Mouse BCL2L11 / BIM
Mouse, Dog, Rat, Human, Monkey
ELISA, Flo, ICC, IHC, IP, WB
Unconjugated
100µg  $385.00
A) Western blot using anti-Bim, mAb (10B12) detecting EE mouse BimS, BimL, BimEL and EE human, BimSS, BimS, BimLS, BimL, BimELS, BimEL. Probing with an anti-Hsp-70 mAb was used as a loading control for all blots. B) Western blot using anti-Bim, mAb (10B12) detecting endogenous Bim expression in mouse tissues but not in Bim knockout mice. Bim protein was revealed in lysates from mouse tissues (5 x 106/lane) and detection by ECL. Probing with an anti-Hsp-70 mAb was used as a loading control.
Flow cytometry data in permeabilized and fixed transfected cells using anti-Bim, mAb (10B12) , anti-EE (positive control) or secondary antibody alone (negative control). Staining was visualized by FITC-conjugated goat anti-rat or anti-mouse IgG antibodies.

BCL2L11 / BIM Antibody (aa20-40, clone 3C5) LS-C344955
Rat Monoclonal [clone 3C5] (IgG2a,k) to Mouse BCL2L11 / BIM
Mouse, Dog, Rat, Human, Monkey
ELISA, Flo, ICC, IHC, IP, WB
Unconjugated
100µg  $385.00
A) Western blot using anti-Bim, mAb (3C5) detecting EE mouse BimS, BimL, BimEL and EE human, BimSS, BimS, BimLS, BimL, BimELS, BimEL. Probing with an anti-Hsp-70 mAb was used as a loading control for all blots. B) Western blot using anti-Bim, mAb (3C5) detecting endogenous Bim expression in mouse tissues but not in Bim knockout mice. Bim protein was revealed in lysates from mouse tissues (5 x 106/lane) and detection by ECL. Probing with an anti-Hsp-70 mAb was used as a loading control.
Flow cytometry data in permeabilized and fixed transfected cells using anti-Bim, mAb (3C5) , anti-EE (positive control) or secondary antibody alone (negative control). Staining was visualized by FITC-conjugated goat anti-rat or anti-mouse IgG antibodies.

BCL2L11 / BIM Antibody LS-C671648
Rabbit Polyclonal (IgG) to Human BCL2L11 / BIM
Human
ELISA, ICC, IF, IHC
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry analysis of human testis tissue at a dilution of 1:100
Immunocytochemistry analysis of human lung cancer at a dilution of 1:100

BCL2L11 / BIM Antibody LS-C4154
Rat Monoclonal (IgG2b) to Mouse BCL2L11 / BIM
Mouse, Human, Monkey
Flo, ICC, IHC, IHC-P, IP, WB
Unconjugated
100µg  $620.00

BCL2L11 / BIM Antibody LS-C4156
Rat Monoclonal (IgG2a) to Mouse BCL2L11 / BIM
Mouse, Human, Monkey
Flo, ICC, IHC, IHC-P, IP, WB
Unconjugated
100µg  $680.00

BCL2L11 / BIM Antibody LS-C201108
Rabbit Polyclonal (IgG) to Human BCL2L11 / BIM
Mouse, Rat, Human
ELISA, ICC, IF, WB
Unconjugated
0.1mg 1mg/ml  $365.00
Immunocytochemistry of BIM EL inK562 cells with BIM EL antibody at 2.5 ug/ml.
Immunofluorescence of BIM EL in K562 cells with BIM EL antibody at 2.5 ug/ml.

BCL2L11 / BIM Antibody (clone 1C2H4) LS-C669047
Mouse Monoclonal [clone 1C2H4] (IgG1) to Human BCL2L11 / BIM
Mouse, Rat, Human
ELISA, ICC, IF, WB
Unconjugated
0.1mg 1mg/ml  $365.00

BCL2L11 / BIM Antibody (HRP) LS-C543734
Rabbit Polyclonal (IgG) to Human BCL2L11 / BIM
Mouse, Rat, Human
WB
HRP Conjugated
100µl  $770.00
Showing 1-25 of 127 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).