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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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BCL2 / Bcl-2

B-cell CLL/lymphoma 2

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

Gene Name: B-cell CLL/lymphoma 2
Family/Subfamily: Apoptosis
Synonyms: BCL2, Apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, B-cell lymphoma protein 2, Bcl-2, PPP1R50
Target Sequences: NM_000633 NP_000624.2 P10415

Publications (3)

1
BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. Deng J, Carlson N, Takeyama K, Dal Cin P, Shipp M, Letai A. Cancer cell. 2007 12:171-85. (IP) [PubMed:17692808]
2
Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule. Zhao L, He F, Liu H, Zhu Y, Tian W, Gao P, He H, Yue W, Lei X, Ni B, Wang X, Jin H, Hao X, Lin J, Chen Q. The Journal of biological chemistry. 2012 287:1054-65. [PubMed:22065578] [PMC:PMC3256916] Related Antibodies: LS-C98842.
3
The Protective Properties of the Strawberry (Fragaria ananassa) against Carbon Tetrachloride-Induced Hepatotoxicity in Rats Mediated by Anti-Apoptotic and Upregulation of Antioxidant Genes Expression Effects. Hamed SS, Al-Yhya NA, El-Khadragy MF, Al-Olayan EM, Alajmi RA, Hassan ZK, Hassan SB, Abdel Moneim AE. Frontiers in physiology. 2016 August;7:325. [Full Text Article] [PubMed:27547187] [PMC:PMC4974471]

Viewing 1-25 of 34 items
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate   $780.00
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate   $720.00
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $530.00
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $650.00
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1plate   $700.00
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.9 - 60 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate   $870.00
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $1,020.00
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $1,050.00
BCL2 / Bcl-2 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1plate   $590.00
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $530.00
BCL2 / Bcl-2 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1plate   $590.00
BCL2 / Bcl-2 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1plate   $590.00
BCL2 / Bcl-2 ELISA Kit
Select
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1plate   $490.00
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
0.41 - 300 ng/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1plate   $940.00
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1plate   $700.00
BCL2 / Bcl-2 ELISA Kit
Select
(1) Publication(s)
Sandwich
96-Well Strip Plate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $700.00
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $700.00
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $700.00
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate   $850.00
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich
96-Well Microplate
Rabbit
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $580.00
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich
96-Well Microplate
Pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $580.00
BCL2 / Bcl-2 ELISA Kit
Select
Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1plate   $700.00
BCL2 / Bcl-2 ELISA Kit
Select
Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1plate   $700.00
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1plate   $700.00
BCL2 / Bcl-2 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1plate   $700.00

Viewing 1-25 of 34 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).