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BCL2 / Bcl-2
B-cell CLL/lymphoma 2
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
| Gene Name: | B-cell CLL/lymphoma 2 |
| Family/Subfamily: | Apoptosis |
| Synonyms: | BCL2, Apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, B-cell lymphoma protein 2, Bcl-2, PPP1R50 |
| Target Sequences: | NM_000633 NP_000624.2 P10415 |
Publications (8)
1
BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. Deng J, Carlson N, Takeyama K, Dal Cin P, Shipp M, Letai A. Cancer cell. 2007 12:171-85. (IP)
[PubMed:17692808]
2
Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule. Zhao L, He F, Liu H, Zhu Y, Tian W, Gao P, He H, Yue W, Lei X, Ni B, Wang X, Jin H, Hao X, Lin J, Chen Q. The Journal of biological chemistry. 2012 287:1054-65.
[PubMed:22065578]
[PMC:PMC3256916]
Related Antibodies: LS-C98842.
3
The Protective Properties of the Strawberry (Fragaria ananassa) against Carbon Tetrachloride-Induced Hepatotoxicity in Rats Mediated by Anti-Apoptotic and Upregulation of Antioxidant Genes Expression Effects. Hamed SS, Al-Yhya NA, El-Khadragy MF, Al-Olayan EM, Alajmi RA, Hassan ZK, Hassan SB, Abdel Moneim AE. Frontiers in physiology. 2016 August;7:325. [Full Text Article]
[PubMed:27547187]
[PMC:PMC4974471]
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ELISA Kits
(32)
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Target
BCL2 / Bcl-2
(32)
Reactivity
Human
(10)
Mouse
(8)
Rat
(7)
Bovine
(2)
Chicken
(2)
Dog
(1)
Guinea pig
(2)
Pig
(1)
Rabbit
(2)
Format
12 x 8-Well Microstrips
(3)
96-Well Microplate
(9)
96-Well Strip Plate
(20)
Publications
No
(30)
Yes
(2)
Sample Type
Adherent Cell Cultures
(4)
Cell Culture Supernatants
(2)
Cell Lysates
(2)
Plasma
(24)
Serum
(24)
Tissue Homogenates
(11)
Sandwich
96-Well Strip Plate
Rat
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$818
Sandwich
96-Well Strip Plate
Mouse
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
Sandwich
96-Well Microplate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
Sandwich
96-Well Strip Plate
Rabbit
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$929
Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$929
Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
Sandwich
96-Well Microplate
Rabbit
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Sandwich
96-Well Microplate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
Sandwich
96-Well Microplate
Pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$627
Sandwich
96-Well Strip Plate
Chicken
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
Sandwich
96-Well Strip Plate
Guinea pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
Sandwich CLIA
96-Well Strip Plate
Human
0.41 - 300 ng/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$968
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Guinea pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Human
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Mouse
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Human
0.9 - 60 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$870
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$870
Sandwich
96-Well Strip Plate
Bovine
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$889
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of 32
product results
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