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BCL10 / BCL-10

B-cell CLL/lymphoma 10

Apoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP. Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF-kB activation. Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing and induces apoptosis through caspase-9 activation. Bcl10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy. Bcl10 is expressed in many human and murine tissues and cell lines.

Gene Name: B-cell CLL/lymphoma 10
Family/Subfamily: Apoptosis
Synonyms: BCL10, Bcl-10, B-cell CLL/lymphoma 10, B-cell lymphoma/leukemia 10, CARMEN, CARD-like apoptotic protein, CCARMEN, C-E10, CIPER, Cellular-E10, HCLAP, Cellular homolog of vCARMEN, CLAP, ME10
Target Sequences: NM_003921 NP_003912.1 O95999

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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
BCL10 / BCL-10 (7)
No (7)
GST (1)
His (1)
His-SUMO (1)
His-T7 (2)
Myc-DDK (Flag) (2)
Human (5)
Mouse (1)
293T Cells (1)
E. coli (4)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (2)
BCL10 / BCL-10 Protein
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E. coli
His-SUMO
42.2 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
BCL10 / BCL-10 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
26.1 kDa
20 µg/$150
BCL10 / BCL-10 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
26.1 kDa
100 µg/$494
BCL10 / BCL-10 Protein - Recombinant  B-Cell CLL/Lymphoma 10 By SDS-PAGE
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E. coli
His-T7
30.0 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
BCL10 / BCL-10 Protein - Recombinant  B-Cell CLL/Lymphoma 10 By SDS-PAGE
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E. coli
His-T7
29.6 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
BCL10 / BCL-10 Protein - 12.5% SDS-PAGE of human BCL10 stained with Coomassie Blue
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Wheat Germ Extract
GST
52.7 kDa
2 µg/$439
BCL10 / BCL-10 Protein
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E. coli
His
10 µg/$361; 50 µg/$739; 20 µg/$486; 100 µg/$1,177; 250 µg/$1,788; 500 µg/$3,043
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).