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BCHE / Cholinesterase

butyrylcholinesterase

Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage.

Gene Name:	butyrylcholinesterase
Synonyms:	BCHE, Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, CHE1, Cholinesterase, Pseudocholinesterase, Butyrylcholinesterase, Cholinesterase 1
Target Sequences:	NM_000055 NP_000046.1 P06276

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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