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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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BCAP / PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
| Gene Name: | phosphoinositide-3-kinase adaptor protein 1 |
| Synonyms: | PIK3AP1, B cell adaptor protein, BCAP, RP11-34E5.3 |
| Target Sequences: | Q6ZUJ8 Q6ZUJ8 |
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