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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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BBC3 / PUMA

BCL2 binding component 3

Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

Gene Name: BCL2 binding component 3
Family/Subfamily: Apoptosis , not assigned-Apoptosis
Synonyms: BBC3, Bcl-2-binding component 3, BCL2 binding component 3, JFY-1, JFY1, PUMA, PUMA alpha
Target Sequences: NM_014417 NP_055232.1 Q9BXH1

Publications (1)

1
Aberrant activation of notch signaling in human breast cancer. Stylianou S, Clarke RB, Brennan K. Cancer research. 2006 66:1517-25. [PubMed:16452208]

Viewing 1-25 of 117 items
BBC3 / PUMA Antibody - Anti-BBC3 / PUMA antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
BBC3 / PUMA Antibody - Anti-BBC3 / PUMA antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Human
IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
BBC3 / PUMA Antibody - Anti-PUMA antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µg   0.5mg/ml   $425.00
BBC3 / PUMA Antibody - Anti-BBC3 / PUMA antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal to Human BBC3 / PUMA
Human
IHC, IHC-P
Unconjugated
50µg   1mg/ml   $425.00
BBC3 / PUMA Antibody - Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with Puma BH3 Domain antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Select
Rabbit Polyclonal to Human BBC3 / PUMA
Mouse, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
BBC3 / PUMA Antibody - PUMA expression in human dysplastic nevi (premalignant melanoma).
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Human
IHC, IHC-P, WB
Unconjugated
100µg   1mg/ml   $335.00
BBC3 / PUMA Antibody - Immunohistochemistry of PUMA in human breast carcinoma with PUMA antibody at 10 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Human
ELISA, IF, IHC, WB
Unconjugated
0.1mg   1mg/ml   $375.00
Select
Rabbit Polyclonal to Human BBC3 / PUMA
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Mouse, Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Mouse, Human
ELISA, IHC, WB
HRP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Mouse, Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Human
ELISA, IHC, WB
HRP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Human
ELISA, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Human
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
BBC3 / PUMA Antibody - BBC3 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human cervix tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
Rabbit Polyclonal to Human BBC3 / PUMA
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal to Human BBC3 / PUMA
Mouse, Human
IF, WB
Unconjugated
100µg   0.5mg/ml   $425.00
Select
Rabbit Polyclonal (IgG) to Human BBC3 / PUMA
Mouse, Human
IHC, WB
Unconjugated
100µg   $485.00

Viewing 1-25 of 117 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).