Products
Services
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

BBC3 / PUMA

BCL2 binding component 3

Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

Gene Name: BCL2 binding component 3
Family/Subfamily: Apoptosis , not assigned-Apoptosis
Synonyms: BBC3, Bcl-2-binding component 3, BCL2 binding component 3, JFY-1, JFY1, PUMA, PUMA alpha
Target Sequences: NM_014417 NP_055232.1 Q9BXH1

Publications (1)

1
Aberrant activation of notch signaling in human breast cancer. Stylianou S, Clarke RB, Brennan K. Cancer research. 2006 66:1517-25. [PubMed:16452208]

☰ Filters
Antibodies (116)
ELISA Kits (20)
Proteins (8)
Competitive EIA (1)
Custom (9)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (4)
Primary (116)
Recombinant (3)
Sandwich (8)
Sandwich CLIA (2)
BBC3 / PUMA (144)
Human (108)
Mouse (53)
Rat (47)
Chicken (1)
Gibbon (3)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sheep (1)
IHC (43)
IHC-P (8)
WB (114)
Flo (1)
ELISA (25)
ICC (19)
IF (5)
IP (2)
Peptide-ELISA (3)
rabbit (111)
mouse (4)
goat (1)
Product Group
IHCPlus (4)
IgG (44)
IgG1 (4)
monoclonal mc (4)
polyclonal pc (112)
10C5G1 (1)
10D4G7 (1)
2A8F6 (1)
2A9G5 (1)
12 x 8-Well Microstrips (2)
96-Well Microplate (2)
96-Well Strip Plate (16)
AP Conjugated (6)
APC (1)
APC Conjugated (6)
Atto 390 Conjugated (2)
Atto 488 Conjugated (2)
Atto 565 Conjugated (2)
Atto 594 Conjugated (4)
Atto 633 Conjugated (2)
Atto 655 Conjugated (2)
Atto 680 Conjugated (2)
Atto 700 Conjugated (2)
Biotin Conjugated (10)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (9)
HRP Conjugated (6)
PE (2)
PE Conjugated (5)
PerCP Conjugated (2)
RPE Conjugated (2)
SA Conjugated (2)
Sepharose Conjugated (1)
Unconjugated (44)
C-Terminus (28)
N-Terminus (19)
aa109-137 (8)
aa119-154 (8)
aa21-70 (4)
Arg169 (1)
C-terminal (1)
aa120-169 (1)
aa145-159 (1)
aa150-193 (1)
aa158-192 (1)
aa178-187 (1)
aa2-16 (1)
No (144)
Cell Lysates (1)
Plasma (9)
Serum (9)
Tissue Homogenates (4)
6His, N-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (6)
Human (5)
Rat (1)
293T Cells (2)
E. coli (1)
HEK 293 Cells (5)
BBC3 / PUMA Antibody - Anti-BBC3 / PUMA antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
BBC3 / PUMA Antibody - Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with Puma BH3 Domain antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) Antibody
Mouse, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$325
BBC3 / PUMA Antibody - PUMA expression in human dysplastic nevi (premalignant melanoma).
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µg/$335
BBC3 / PUMA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$740
Select
HEK 293 Cells
6His, N-terminus
30-40 kDa
200 µl/$235
BBC3 / PUMA Antibody - Immunohistochemistry of PUMA in human breast carcinoma with PUMA antibody at 10 ug/ml.
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$375
BBC3 / PUMA Antibody - Anti-BBC3 / PUMA antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa2-16) Antibody
Human
IHC, IHC-P, WB
Unconjugated
0.05 mg/$425
BBC3 / PUMA Antibody - Anti-PUMA antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$425
BBC3 / PUMA Antibody - Anti-BBC3 / PUMA antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$425
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$325
BBC3 / PUMA Protein - Purified recombinant protein BBC3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
20.4 kDa
20 µg/$890
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$590
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
200 µl/$740
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$740
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$740
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$740
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) (AP) Antibody
Human
ELISA, IHC, WB
AP Conjugated
200 µl/$740
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$740
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$590
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated
200 µl/$740
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$740
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$740
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$740
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$740
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) (AP) Antibody
Mouse, Human
ELISA, IHC, WB
AP Conjugated
200 µl/$740
Viewing 1-25 of 144 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).