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BBC3 / PUMA
BCL2 binding component 3
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
| Gene Name: | BCL2 binding component 3 |
| Family/Subfamily: | Apoptosis , not assigned-Apoptosis |
| Synonyms: | BBC3, Bcl-2-binding component 3, BCL2 binding component 3, JFY-1, JFY1, PUMA, PUMA alpha |
| Target Sequences: | NM_014417 NP_055232.1 Q9BXH1 |
Publications (2)
1
Aberrant activation of notch signaling in human breast cancer. Stylianou S, Clarke RB, Brennan K. Cancer research. 2006 66:1517-25.
[PubMed:16452208]
2
Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia. Ernesto Diaz-Flores, Evan Q Comeaux, Kailyn L Kim, Ella Melnik, Kyle Beckman, Kara L Davis, Kevin Wu, Jon Akutagawa, Olga Bridges, Roberta Marino, Margo Wohlfeil, Benjamin S Braun, Charles G Mullighan, Mignon L Loh. Cancer research. 2019 May;79:2339-2351. [Full Text Article]
[PubMed:30862722]
[PMC:PMC6497548]
Related Antibodies: LS-C98860.
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BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) Antibody
Mouse, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µg/$386
HEK 293 Cells
6His, N-terminus
30-40 kDa
200 µl/$283
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa2-16) Antibody
Human
IHC, IHC-P, WB
Unconjugated
0.05 mg/$495
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$386
HEK 293 Cells
Myc-DDK (Flag)
20.4 kDa
20 µg/$1,107
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated
200 µl/$952
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
200 µl/$952
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
100 µg/$583
BBC3 / PUMA Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, WB
Unconjugated
25 µg/$320; 100 µg/$442
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