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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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BAK1 / BAK

BCL2-antagonist/killer 1

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bak, a pro-apoptotic Bcl-2 family member, is an oligomeric protein that localizes to the mitochondria. It is thought to share significant functional homology with Bax, another pro-apoptotic Bcl-2 family member, as disruption of bak or bax has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking bak and bax show decreased apoptotic capability.

Gene Name: BCL2-antagonist/killer 1
Synonyms: BAK1, Apoptosis regulator BAK, BAK, BCL2L7, Bcl-2-like protein 7, BCL2-antagonist/killer 1, Bcl2-L-7, BCL2-like 7 protein, CDN1, Pro-apoptotic protein BAK, BAK-LIKE
Target Sequences: NM_001188 NP_001179.1 Q16611

Publications (1)

1
Dissociation of Bak a1 helix from the core and latch domains is required for apoptosis. Alsop AE, Fennell SC, Bartolo RC, Tan IK, Dewson G, Kluck RM. Nature communications. 2015 6:6841. (IHC; Human) [Full Text Article] [PubMed:25880232] Related Antibodies: LS-C12099.

Filtered by: None
Type
Over-Expression Lysate (3)
Recombinant (3)
Target
BAK1 / BAK (6)
Tag
6His,N-terminus (1)
8His,N-terminus (1)
GST (1)
GST,N-terminus (1)
Myc + DDK (2)
Species
Human (5)
Source
293T Cells (1)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purification
Purified (1)
Showing 1-6 of 6 results

Human BAK1 / BAK Protein (Recombinant GST,N-terminus) (aa100-211) - LS-G57873
Wheat Germ Extract
GST,N-terminus
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.

Human BAK1 / BAK Protein (Over-Expression Lysate 8His,N-terminus) (Ala2-Pro187) - LS-G26694
HEK 293 Cells
8His,N-terminus
22.9 kDa
100µg  $245.00

Human BAK1 / BAK Protein (Recombinant 6His,N-terminus) (Ala2-Pro187) - LS-G26835
HEK 293 Cells
6His,N-terminus
22.9 kDa
200µl  $235.00

Human BAK1 / BAK Protein (Recombinant GST) (Full Length) - LS-G27598
Wheat Germ Extract
GST
49.8 kDa
10µg  $415.00; 25µg  $590.00
12.5% SDS-PAGE of human BAK1 stained with Coomassie Blue

Human BAK1 / BAK Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G74721
293T Cells
Myc + DDK
23.2 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

BAK1 / BAK Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G99361
HEK 293 Cells
Myc + DDK
23.2 kDa
100µg  $345.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Showing 1-6 of 6 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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