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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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BAK1 / BAK

BCL2-antagonist/killer 1

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bak, a pro-apoptotic Bcl-2 family member, is an oligomeric protein that localizes to the mitochondria. It is thought to share significant functional homology with Bax, another pro-apoptotic Bcl-2 family member, as disruption of bak or bax has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking bak and bax show decreased apoptotic capability.

Gene Name: BCL2-antagonist/killer 1
Synonyms: BAK1, Apoptosis regulator BAK, BAK, BCL2L7, Bcl-2-like protein 7, BCL2-antagonist/killer 1, Bcl2-L-7, BCL2-like 7 protein, CDN1, Pro-apoptotic protein BAK, BAK-LIKE
Target Sequences: NM_001188 NP_001179.1 Q16611

Publications (1)

1
Dissociation of Bak a1 helix from the core and latch domains is required for apoptosis. Alsop AE, Fennell SC, Bartolo RC, Tan IK, Dewson G, Kluck RM. Nature communications. 2015 6:6841. (IHC; Human) [Full Text Article] [PubMed:25880232] Related Antibodies: LS-C12099.

Filtered by: None
Type
Cell-Based (1)
Custom (4)
Sandwich (7)
Sandwich CLIA (1)
Target
BAK1 / BAK (13)
Reactivity
Human (6)
Mouse (2)
Rat (2)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sample Type
Adherent Cell Cultures (1)
Cell Lysates (1)
Plasma (7)
Serum (7)
Tissue Homogenates (3)
Showing 1-13 of 13 results

Human BAK1 / BAK ELISA Kit (Sandwich ELISA) - LS-F8065
Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1plate  $790.00
LSBio image for ELISA Kit

Mouse/Human BAK1 / BAK ELISA Kit (Cell-Based ELISA) - LS-F1819
Cell-Based
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1plate  $490.00
LSBio image for ELISA Kit

Human BAK1 / BAK ELISA Kit (Sandwich ELISA) - LS-F22569
Sandwich
96-Well Microplate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate  $590.00
LSBio image for ELISA Kit

Human BAK1 / BAK ELISA Kit (Sandwich ELISA) - LS-F26717
Sandwich
96-Well Strip Plate
Human
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate  $870.00
LSBio image for ELISA Kit

Human BAK1 / BAK ELISA Kit (CLIA) - LS-F29464
Sandwich CLIA
12 x 8-Well Microstrips
Human
0.156 - 10 ng/ml
Chemiluminescent
Plasma, Serum
1plate  $700.00
LSBio image for ELISA Kit

Porcine BAK1 / BAK ELISA Kit (Custom ELISA) - LS-F41607
Custom
96-Well Strip Plate
Porcine
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1plate  $660.00
LSBio image for ELISA Kit

Guinea pig BAK1 / BAK ELISA Kit (Custom ELISA) - LS-F41605
Custom
96-Well Strip Plate
Guinea pig
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1plate  $660.00
LSBio image for ELISA Kit

Rabbit BAK1 / BAK ELISA Kit (Custom ELISA) - LS-F41608
Custom
96-Well Strip Plate
Rabbit
7.813 - 500 ng/ml
Colorimetric - 450nm (TMB)
1plate  $660.00
LSBio image for ELISA Kit

Monkey BAK1 / BAK ELISA Kit (Custom ELISA) - LS-F41606
Custom
96-Well Strip Plate
Monkey
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1plate  $660.00
LSBio image for ELISA Kit

Mouse BAK1 / BAK ELISA Kit (Sandwich ELISA) - LS-F38257
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate  $600.00
LSBio image for ELISA Kit

Rat BAK1 / BAK ELISA Kit (Sandwich ELISA) - LS-F38588
Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate  $600.00
LSBio image for ELISA Kit

Human BAK1 / BAK ELISA Kit (Sandwich ELISA) - LS-F35419
Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate  $790.00
LSBio image for ELISA Kit

Rat BAK1 / BAK ELISA Kit (Sandwich ELISA) - LS-F35420
Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate  $790.00
LSBio image for ELISA Kit
Showing 1-13 of 13 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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