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BAK1 / BAK

BCL2-antagonist/killer 1

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bak, a pro-apoptotic Bcl-2 family member, is an oligomeric protein that localizes to the mitochondria. It is thought to share significant functional homology with Bax, another pro-apoptotic Bcl-2 family member, as disruption of bak or bax has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking bak and bax show decreased apoptotic capability.

Gene Name: BCL2-antagonist/killer 1
Synonyms: BAK1, Apoptosis regulator BAK, BAK, BCL2L7, Bcl-2-like protein 7, BCL2-antagonist/killer 1, Bcl2-L-7, BCL2-like 7 protein, CDN1, Pro-apoptotic protein BAK, BAK-LIKE
Target Sequences: NM_001188 NP_001179.1 Q16611

Publications (1)

1
Dissociation of Bak a1 helix from the core and latch domains is required for apoptosis. Alsop AE, Fennell SC, Bartolo RC, Tan IK, Dewson G, Kluck RM. Nature communications. 2015 6:6841. (IHC; Human) [Full Text Article] [PubMed:25880232] Related Antibodies: LS-C12099.

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BAK1 / BAK ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
BAK1 / BAK ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
BAK1 / BAK ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
0.156 - 10 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
BAK1 / BAK ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
BAK1 / BAK ELISA Kit
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Sandwich
96-Well Microplate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
BAK1 / BAK ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
BAK1 / BAK ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
BAK1 / BAK ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
BAK1 / BAK ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
7.813 - 500 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
BAK1 / BAK ELISA Kit
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Sandwich
96-Well Strip Plate
Human
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
BAK1 / BAK ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
BAK1 / BAK ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
BAK1 / BAK ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
BAK1 / BAK ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
BAK1 / BAK ELISA Kit
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Custom
96-Well Strip Plate
Mouse
1 Plate/$783
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).