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BAG3 / BAG-3
BCL2-associated athanogene 3
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
| Gene Name: | BCL2-associated athanogene 3 |
| Synonyms: | BAG3, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, BCL2-binding athanogene 3, BIS, BAG-3, CAIR-1, Docking protein cair1, BCL2-associated athanogene 3, Docking protein CAIR-1 |
| Target Sequences: | NM_004281 NP_004272.2 O95817 |
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