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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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BAD

BCL2-associated agonist of cell death

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain containing pro-apoptotic proteins, such as Bax, Bid, and Bik, form a growing subclass of the Bcl-2 family. Another such protein is the Bcl-2-antagonist of cell death (Bad). Bad regulates apoptosis by forming heterodimers with anti-apoptotic proteins Bcl-2 and Bcl-xL, thereby preventing them from binding with Bax. Bad activity is regulated by its phosphorylation; it is inactivated by kinases such as Akt and MAP kinase and thus promotes cell survival, whereas JNK-induced phosphorylation promotes the apoptotic role of Bad.

Gene Name: BCL2-associated agonist of cell death
Family/Subfamily: Apoptosis , Not assigned-Other
Synonyms: BAD, BBC2, Bcl-2-like protein 8, BCL2-binding component 6, BCL2L8, BBC6, BCL-X/BCL-2 binding protein, Bcl-2-binding component 6, Bcl2 antagonist of cell death, BCL2-binding protein, Bcl2-L-8
Target Sequences: NM_004322 NP_004313.1 Q92934

Publications (1)

1
Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons. Miyawaki T, Mashiko T, Ofengeim D, Flannery RJ, Noh KM, Fujisawa S, Bonanni L, Bennett MV, Zukin RS, Jonas EA. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:4892-7. (WB, IP) [PubMed:18347331] [PMC:PMC2290755]

Viewing 1-13 of 13 items
BAD Protein - Purified recombinant protein BAD was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc + DDK
18.2 kDa
20µg   $890.00
Select
293T Cells
Myc + DDK
18.2 kDa
20µg   $195.00
BAD Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
18.2 kDa
20µg   $195.00
Select
293T Cells
Myc + DDK
18.2 kDa
20µg   $195.00
Select
HEK 293 Cells
8His,N-terminus
20.7 kDa
100µg   $245.00
BAD Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST,N-terminus
10µg   $425.00; 25µg   $590.00
BAD Protein - Recombinant  Bcl2 Associated Death Promoter By SDS-PAGE
Select
E. coli
His + T7
22.2 kDa
10µg   $275.00; 50µg   $455.00; 100µg   $605.00; 200µg   $875.00; 1mg   $2,265.00; 500µg   $1,005.00
BAD Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc + DDK
18.2 kDa
100µg   $365.00
BAD Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc + DDK
18.2 kDa
100µg   $365.00
BAD Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc + DDK
18.2 kDa
100µg   $365.00
BAD Protein
Select
E. coli
His, N-Terminal
18.2 kDa
50µg   $325.00
BAD Protein - 12.5% SDS-PAGE of human BAD stained with Coomassie Blue
Select
Wheat Germ Extract
GST
44.11 kDa
2µg   $385.00
Select
E. coli
GST
51.0 kDa
2µg   $305.00; 5µg   $375.00; 10µg   $590.00

Viewing 1-13 of 13 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).