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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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BAD

BCL2-associated agonist of cell death

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain containing pro-apoptotic proteins, such as Bax, Bid, and Bik, form a growing subclass of the Bcl-2 family. Another such protein is the Bcl-2-antagonist of cell death (Bad). Bad regulates apoptosis by forming heterodimers with anti-apoptotic proteins Bcl-2 and Bcl-xL, thereby preventing them from binding with Bax. Bad activity is regulated by its phosphorylation; it is inactivated by kinases such as Akt and MAP kinase and thus promotes cell survival, whereas JNK-induced phosphorylation promotes the apoptotic role of Bad.

Gene Name: BCL2-associated agonist of cell death
Family/Subfamily: Apoptosis , Not assigned-Other
Synonyms: BAD, BBC2, Bcl-2-like protein 8, BCL2-binding component 6, BCL2L8, BBC6, BCL-X/BCL-2 binding protein, Bcl-2-binding component 6, Bcl2 antagonist of cell death, BCL2-binding protein, Bcl2-L-8
Target Sequences: NM_004322 NP_004313.1 Q92934

Publications (1)

1
Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons. Miyawaki T, Mashiko T, Ofengeim D, Flannery RJ, Noh KM, Fujisawa S, Bonanni L, Bennett MV, Zukin RS, Jonas EA. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:4892-7. (WB, IP) [PubMed:18347331] [PMC:PMC2290755]

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BAD (397)
No (397)
Viewing 1-25 of 397 items
BAD Antibody - Anti-BAD antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Neuroscience
Rabbit Polyclonal (IgG) to Human BAD
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
BAD Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal to Mouse BAD
Drosophila, Pig, Rat, Hamster, Rabbit, Mouse, Dog, Sheep, Bovine, Monkey
IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $425.00
BAD Antibody - Anti-BAD antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal (IgG) to Human BAD
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
BAD Antibody - Anti-BAD antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Rabbit Polyclonal (IgG) to Human BAD
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50µl   1mg/ml   $425.00
BAD Antibody - Anti-BAD antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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Rabbit Polyclonal (IgG) to Human BAD
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
BAD Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Rabbit Polyclonal to Human BAD
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
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Rabbit Monoclonal (IgG) to Mouse BAD
Mouse, Human
ELISA, WB
Unconjugated
200µl   $590.00
BAD Antibody - Western blot analysis of extracts of HeLa cells, using BAD antibody.
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Mouse Monoclonal to Human BAD
Mouse, Rat, Human
IF, IHC, IP, WB
Unconjugated
50µl   $265.00; 100µl   $345.00; 200µl   $445.00
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Rabbit Polyclonal (IgG) to Mouse BAD
Mouse, Rat, Human, Monkey
ELISA, IP, WB
Unconjugated
100µl   $530.00
Select
Rabbit Monoclonal (IgG) to Human BAD
Mouse, Rat, Human
ELISA, WB
Unconjugated
20µl   $395.00; 100µl   $605.00
BAD Antibody
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Rabbit Polyclonal (IgG) to Human BAD
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
BAD Antibody
Select
Rabbit Polyclonal (IgG) to Human BAD
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
BAD Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using BAD (Phospho-Ser134) antibody.
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Rabbit Polyclonal (IgG) to Human BAD
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $305.00
BAD Antibody
Select
Rabbit Polyclonal (IgG) to Human BAD
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal to Human BAD
Human
ICC, IF, IHC, IP, WB
Unconjugated
50µl   $325.00
BAD Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using BAD (Phospho-Ser134) Antibody. The picture on the right is blocked with the phospho peptide.
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Rabbit Polyclonal (IgG) to Human BAD
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
Select
Rabbit Polyclonal (IgG) to Human BAD
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human BAD
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human BAD
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
BAD Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Select
Rabbit Polyclonal to Human BAD
Human
DB, IF, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
BAD Antibody - Western Blot (WB) analysis of specific cells using Phospho-Bad (S155) polyclonal antibody.
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Rabbit Polyclonal (IgG) to Human BAD
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
BAD Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Select
Rabbit Polyclonal to Human BAD
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
BAD Antibody - Immunohistochemistry of paraffin-embedded rat kidney using BAD antibodyat dilution of 1:200 (40x lens).
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Rabbit Polyclonal (IgG) to Human BAD
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50µl   $235.00; 100µl   $315.00; 200µl   $425.00
BAD Antibody - IHC of BAD (P130) pAb in paraffin-embedded human brain tissue.
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Rabbit Polyclonal to Human BAD
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   $345.00
BAD Antibody - Immunofluorescence microscopy of BAD using Polyclonal Antibody to BAD at 1:2000. Du145 human prostate carcinoma cells were cultured without (A) or with (B and C) 1 uM of the triphosphatase inhibitor thapsigargin (THG) for 12 hr. A and B, staining with BAD antibody, followed by a FITC-conjugated secondary antibody. C, staining with a mitochondrial marker (antibody to mitochondrial Hsp60), followed by a rhodamine-conjugated secondary antibody. THG induces Ca2+ release from internal stores which can promote apoptosis. BAD staining was located diffusely throughout the cytoplasm of untreated cells (A), and localized to the mitochondria in treated cells (B).
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Rabbit Polyclonal to Human BAD
Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50µl   $335.00

Viewing 1-25 of 397 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).