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Shirley, MA 01464
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20700 44th Avenue W
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BACE2
beta-site APP-cleaving enzyme 2
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
| Gene Name: | beta-site APP-cleaving enzyme 2 |
| Family/Subfamily: | Protease , Aspartic A1 |
| Synonyms: | BACE2, 56 kDa aspartic-like protease, AEPLC, ALP56, Aspartic-like protease 56 kDa, APL56, BAE2, Beta-secretase 2, ASP21, CDA13, DRAP, Memapsin-1, Asp 1, ASP1, Aspartyl protease 1, Theta-secretase, Beta secretase 2, CEAP1, Down region aspartic protease |
| Target Sequences: | NM_012105 NP_036237.2 Q9Y5Z0 |
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