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BACE1 / BACE

beta-site APP-cleaving enzyme 1

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

Gene Name: beta-site APP-cleaving enzyme 1
Family/Subfamily: Protease , Aspartic A1
Synonyms: BACE1, APP beta-secretase, Asp 2, ASP2, Aspartyl protease 2, Aspartylprotease 2, Beta-secretase, Beta-site APP-cleaving enzyme, BACE, HSPC104, KIAA1149, B-Secretase, Beta-secretase 1, Memapsin-2
Target Sequences: NM_012104 NP_036236.1 P56817

Publications (1)

1
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. Kuzuya A, Zoltowska KM, Post KL, Arimon M, Li X, Svirsky S, Maesako M, Muzikansky A, Gautam V, Kovacs D, Hyman BT, Berezovska O. BMC biology. 2016 14:25. (WB; Human) [Full Text Article] [PubMed:27036734] [PMC:PMC4818459]

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Products
Proteins (18)
Over-Expression Lysate (8)
Recombinant (10)
BACE1 / BACE (18)
No (18)
Fc (1)
GST (1)
His (3)
His,C-terminus (1)
His-GST (2)
Myc-DDK (Flag) (9)
Human (11)
Mouse (2)
Rat (1)
293T Cells (4)
E. coli (4)
HEK 293 Cells (7)
Human Cells (2)
Wheat Germ Extract (1)
Purified (4)
Low endotoxin level (5)
BACE1 / BACE Protein - Purified recombinant protein BACE1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
51 kDa
20 µg/$1,107
BACE1 / BACE Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
55.76 kDa
20 µg/$150
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293T Cells
Myc-DDK (Flag)
46.3 kDa
20 µg/$150
BACE1 / BACE Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
46.3 kDa
20 µg/$215
BACE1 / BACE Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
43.4 kDa
20 µg/$215
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Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
49.9 kDa
100 µg/$721
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Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
75 kDa
100 µg/$721
BACE1 / BACE Protein - Recombinant Beta-Site APP Cleaving Enzyme 1 By SDS-PAGE
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E. coli
His-GST
59.1 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
BACE1 / BACE Protein - 12.5% SDS-PAGE of human BACE1 stained with Coomassie Blue
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Wheat Germ Extract
GST
78.54 kDa
10 µg/$479; 25 µg/$670
BACE1 / BACE Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
46.3 kDa
100 µg/$710
BACE1 / BACE Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
43.4 kDa
100 µg/$710
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HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
49.8 kDa
100 µg/$721
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HEK 293 Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
49 kDa
100 µg/$721
BACE1 / BACE Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
46.3 kDa
100 µg/$494
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E. coli
153 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
16.94 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
BACE1 / BACE Protein - Recombinant Beta-Site APP Cleaving Enzyme 1 By SDS-PAGE
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E. coli
His-GST
59.0 kDa
10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170
BACE1 / BACE Protein - Recombinant Beta-Site APP Cleaving Enzyme 1 By SDS-PAGE
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E. coli
His
22.4 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
BACE1 / BACE Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
55.76 kDa
100 µg/$494
Viewing 1-18 of 18 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).