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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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BACE1 / BACE

beta-site APP-cleaving enzyme 1

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

Gene Name: beta-site APP-cleaving enzyme 1
Family/Subfamily: Protease , Aspartic A1
Synonyms: BACE1, APP beta-secretase, Asp 2, ASP2, Aspartyl protease 2, Aspartylprotease 2, Beta-secretase, Beta-site APP-cleaving enzyme, BACE, HSPC104, KIAA1149, B-Secretase, Beta-secretase 1, Memapsin-2
Target Sequences: NM_012104 NP_036236.1 P56817

Publications (1)

1
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. Kuzuya A, Zoltowska KM, Post KL, Arimon M, Li X, Svirsky S, Maesako M, Muzikansky A, Gautam V, Kovacs D, Hyman BT, Berezovska O. BMC biology. 2016 14:25. (WB; Human) [Full Text Article] [PubMed:27036734] [PMC:PMC4818459]

Filtered by: None
Target
BACE1 / BACE (109)
Reactivity
Human (90)
Mouse (42)
Rat (41)
Bat (15)
Bovine (15)
Chicken (4)
Chimpanzee (6)
Dog (11)
Gibbon (7)
Guinea pig (15)
Hamster (15)
Horse (15)
Monkey (31)
Pig (15)
Primate (1)
Rabbit (15)
Xenopus (4)
Zebrafish (5)
Application
IHC (44)
IHC-P (29)
WB (71)
Flo (6)
ELISA (33)
ICC (5)
IF (7)
IP (5)
Neut (1)
Peptide-ELISA (1)
Host
rabbit (102)
mouse (7)
Isotype
IgG (34)
IgG1 (6)
Clonality
monoclonal mc (8)
polyclonal pc (101)
Clone
3C1C3 (1)
61-3E7 (1)
Format
AP Conjugated (5)
APC (3)
APC Conjugated (8)
Azide-free (4)
Biotin Conjugated (11)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (12)
HRP Conjugated (11)
PE Conjugated (9)
Unconjugated (47)
Epitope
aa170-428 (8)
aa181-366 (8)
aa190-430 (8)
C-Terminus (7)
Internal (7)
N-Terminus (7)
pSer498 (7)
aa251-300 (4)
aa72-121 (4)
440-520 aa (1)
Asp492 (1)
Ser498 (1)
aa22-322 (1)
aa38-70 (1)
aa452-501 (1)
Publications
No (109)
Showing 1-25 of 109 results

IHC-plus™ BACE1 / BACE Antibody (N-Terminus) LS-A8548
Rabbit Polyclonal to Human BACE1 / BACE
Rat, Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ BACE1 / BACE Antibody (N-Terminus, AP) LS-A108023
Rabbit Polyclonal to Human BACE1 / BACE
Rat, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl  $650.00
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ BACE1 / BACE Antibody (N-Terminus, APC) LS-A108024
Rabbit Polyclonal to Human BACE1 / BACE
Rat, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl  $650.00
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ BACE1 / BACE Antibody (aa72-121) LS-B4664
Rabbit Polyclonal to Human BACE1 / BACE
Rabbit, Mouse, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl 0.5mg/ml  $485.00
Anti-BACE1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-BACE1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHC-plus™ BACE1 / BACE Antibody (Internal) LS-A8893
Rabbit Polyclonal to Human BACE1 / BACE
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-BACE1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

BACE1 / BACE Antibody LS-C74520
Mouse Monoclonal (IgG1) to Human BACE1 / BACE
Mouse, Human
ELISA, IP, Neut, WB
Unconjugated
100µg  $740.00

BACE1 / BACE Antibody (aa22-322) LS-C346301
Rabbit Polyclonal (IgG) to Human BACE1 / BACE
Zebrafish, Mouse, Human
IHC, IP, WB
Unconjugated
50µl  $305.00; 100µl  $345.00
Western blot of extracts of Mouse brain cell line, using BACE1 antibody.

IHC-plus™ BACE1 / BACE Antibody (C-Terminus) LS-A8549
Rabbit Polyclonal to Human BACE1 / BACE
Human, Monkey
IHC, IHC-P
Unconjugated
50µg 1mg/ml  $425.00
Anti-BACE1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)

BACE1 / BACE Antibody LS-C3879
Mouse Monoclonal (IgG1) to Human BACE1 / BACE
Human
ELISA, Flo, WB
Unconjugated
100µg  $680.00; 500µg  $1,410.00

BACE1 / BACE Antibody LS-C12062
Rabbit Polyclonal (IgG) to Mouse BACE1 / BACE
Mouse
ELISA, WB
Unconjugated
100µg  $755.00

BACE1 / BACE Antibody LS-C403859
Rabbit Polyclonal (IgG) to Human BACE1 / BACE
Mouse, Rat, Human
ELISA, WB
Unconjugated
20µl 0.3mg/ml  $205.00; 60µl 0.3mg/ml  $235.00; 120µl 0.3mg/ml  $295.00; 200µl 0.3mg/ml  $395.00
Western blot analysis of Human fetal brain tissue, using BACE1 Polyclonal Antibody at dilution of 1:500.

BACE1 / BACE Antibody (aa452-501) LS-C198667
Rabbit Polyclonal (IgG) to Human BACE1 / BACE
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using BACE Antibody. The picture on the right is blocked with the synthesized peptide.
Immunofluorescence analysis of HUVEC cells, using BACE Antibody. The picture on the right is blocked with the synthesized peptide.

BACE1 / BACE Antibody LS-C126949
Mouse Monoclonal (IgG1) to Human BACE1 / BACE
Human
ELISA, Flo, WB
Unconjugated
100µg  $755.00

BACE1 / BACE Antibody LS-C377
Rabbit Polyclonal (IgG) to Human BACE1 / BACE
Mouse, Human
ELISA, ICC, IF, IHC, WB
Unconjugated
0.1mg 1mg/ml  $365.00
Immunohistochemistry of BACE in mouse brain tissue with BACE antibody at 2.5 µg/ml.
Immunocytochemistry of BACE in 3T3 cells with BACE antibody at 10 µg/ml.

BACE1 / BACE Antibody LS-C126948
Rabbit Monoclonal (IgG) to Human BACE1 / BACE
Mouse, Rat, Human
IP, WB
Unconjugated
20µl  $395.00; 100µl  $605.00

BACE1 / BACE Antibody LS-C355637
Rabbit Polyclonal (IgG) to Human BACE1 / BACE
Human, Monkey, Gibbon
ELISA, ICC, IF, IP, WB
Unconjugated
100µg  $445.00
IF using BACE1 Antibody
IF using BACE1 Antibody

BACE1 / BACE Antibody (aa251-300) LS-C116864
Rabbit Polyclonal to Mouse BACE1 / BACE
Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Hamster, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
WB
Unconjugated
100µl 0.5mg/ml  $385.00
BACE1 antibody Western blot of Mouse Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

BACE1 / BACE Antibody (aa170-428) LS-C372590
Rabbit Polyclonal to Human BACE1 / BACE
Human
WB
Unconjugated
20µl 0.5mg/ml  $195.00; 100µl 0.5mg/ml  $245.00; 200µl 0.5mg/ml  $285.00; 1ml 0.5mg/ml  $475.00
Western blot of BACE1 / BACE antibody.

BACE1 / BACE Antibody LS-C483690
Rabbit Polyclonal to Mouse BACE1 / BACE
Mouse
ELISA, IHC, IHC-P, WB
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

BACE1 / BACE Antibody LS-C498437
Rabbit Polyclonal (IgG) to Human BACE1 / BACE
Human
ELISA, IF, IHC
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using BACE1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human melanoma cancer using BACE1 Antibody at dilution of 1:100

BACE1 / BACE Antibody LS-C659596
Rabbit Polyclonal (IgG) to Human BACE1 / BACE
Human
ELISA, IHC, IP, WB
Unconjugated
100µg  $435.00

BACE1 / BACE Antibody LS-C483688
Rabbit Polyclonal to Human BACE1 / BACE
Human
Flo, ICC, IF
Unconjugated
50µl  $275.00; 100µl  $355.00

BACE1 / BACE Antibody (440-520 aa) LS-C382240
Rabbit Polyclonal (IgG) to Human BACE1 / BACE
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00

BACE1 / BACE Antibody (Asp492) LS-C176262
Rabbit Polyclonal to Human BACE1 / BACE
Mouse, Rat, Human
IF, IHC, IHC-P
Unconjugated
100µl  $345.00
IHC of BACE (D492) pAb in paraffin-embedded human brain tissue.

BACE1 / BACE Antibody (phospho-Ser498) LS-C326901
Rabbit Polyclonal (IgG) to Human BACE1 / BACE
Human
ELISA, IHC, WB
Unconjugated
200µl  $590.00
Showing 1-25 of 109 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).