B4GALT1

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1

B4GALT1 is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

B4GALT1 (8)

Publications

No (8)

Tag

6His, C-terminus (1)

GST (1)

GST, N-terminus (2)

GST, N-terminus + His, C-terminus (1)

His,N-terminus (1)

Myc-DDK (Flag) (2)

Species

Bovine (2)

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Human (1)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (2)

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Human B4GALT1 Protein (Recombinant GST, N-terminus) (aa44-153) - LS-G58685

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human B4GALT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74750

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.7 kDa

Price:

20 µg/$150

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Bovine B4GALT1 Protein (Recombinant GST) (Full Length) - LS-G20514

Source:

E. coli

Tag:

GST

Molecular Weight:

29.95 kD

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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B4GALT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99459

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.7 kDa

Price:

100 µg/$494

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Bovine B4GALT1 Protein (Recombinant GST, N-terminus) - LS-G136571

Source:

Yeast

Tag:

GST, N-terminus

Molecular Weight:

29.5 kDa

Price:

100 µg/$570; 20 µg/$395; 1 mg/$1,973

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Human B4GALT1 Protein (Recombinant His,N-terminus) (Gly44-Ser398) - LS-G138426

Source:

HEK 293 Cells

Tag:

His,N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

41.5 kDa

Price:

20 µg/$603

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Human B4GALT1 Protein (Recombinant 6His, C-terminus) - LS-G146037

Source:

Human

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

40.1 kDa

Price:

10 µg/$344; 50 µg/$657

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Human B4GALT1 Protein (Recombinant GST, N-terminus + His, C-terminus) - LS-G145258

Source:

E. coli

Tag:

GST, N-terminus + His, C-terminus

Molecular Weight:

71.7 kDa

Price:

50 µg/$419

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