B4GALT1

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1

B4GALT1 is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase.

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ELISA Kits (8)

Type

Custom (5)

Sandwich (3)

Target

B4GALT1 (8)

Reactivity

Human (4)

Mouse (2)

Rat (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (6)

Publications

No (8)

Sample Type

Cell Culture Supernatants (1)

EDTA Plasma (1)

Heparin Plasma (1)

Plasma (2)

Serum (3)

Tissue Homogenates (2)

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Human B4GALT1 (Sandwich ELISA) ELISA Kit - LS-F5021

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$798

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Rat B4GALT1 (Custom ELISA) ELISA Kit - LS-F20430

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human B4GALT1 (Custom ELISA) ELISA Kit - LS-F20432

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Mouse B4GALT1 (Custom ELISA) ELISA Kit - LS-F20429

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Bovine B4GALT1 (Custom ELISA) ELISA Kit - LS-F20431

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Mouse B4GALT1 (Sandwich ELISA) ELISA Kit - LS-F32708

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human B4GALT1 (Sandwich ELISA) ELISA Kit - LS-F57335

Type:

Sandwich

Reactivity:

Human

Range:

156 - 10000 pg/ml

Sample Types:

Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum

Price:

1 Plate/$1,150

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Human B4GALT1 (Custom ELISA) ELISA Kit - LS-F50429

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$672

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