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B2M / Beta 2 Microglobulin

beta-2-microglobulin

B2M / Beta 2 Microglobulin is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.

Gene Name:	beta-2-microglobulin
Synonyms:	B2M, Beta 2 Microglobulin, Beta-2-microglobulin, Beta-2-microglobin
Target Sequences:	NM_004048 NP_004039.1 P61769

Publications (9)

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Meissner TB, Li A, Biswas A, Lee KH, Liu YJ, Bayir E, Iliopoulos D, van den Elsen PJ, Kobayashi KS. Proceedings of the National Academy of Sciences of the United States of America. 2010 107:13794-9. [PubMed:20639463] [PMC:PMC2922274] Related Antibodies: LS-B2200.

Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules. Rizvi SM, Del Cid N, Lybarger L, Raghavan M. Journal of immunology (Baltimore, Md. : 1950). 2011 186:2309-20. [PubMed:21263072] [PMC:PMC3057457] Related Antibodies: LS-B2200.

NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression. Meissner TB, Liu YJ, Lee KH, Li A, Biswas A, van Eggermond MC, van den Elsen PJ, Kobayashi KS. Journal of immunology (Baltimore, Md. : 1950). 2012 188:4951-8. [PubMed:22490869] [PMC:PMC3345046] Related Antibodies: LS-B2200.

Young bone marrow transplantation preserves learning and memory in old mice. Das MM, Godoy M, Chen S, Moser VA, Avalos P, Roxas KM, Dang I, Yáñez A, Zhang W, Bresee C, Arditi M, Liu GY, Svendsen CN, Goodridge HS. Communications biology. 2019 February;2:73. [Full Text Article] [PubMed:30820468] [PMC:PMC6382867]

Platelet-derived ß2M regulates monocyte inflammatory responses. Hilt ZT, Pariser DN, Ture SK, Mohan A, Quijada P, Asante AA, Cameron SJ, Sterling JA, Merkel AR, Johanson AL, Jenkins JL, Small EM, McGrath KE, Palis J, Elliott MR, Morrell CN. JCI insight. 2019 March;4:pii: 122943. [Full Text Article] [PubMed:30702442] [PMC:PMC6483513]

Platelet-derived ß2m regulates age related monocyte/macrophage functions. Hilt ZT, Ture SK, Mohan A, Arne A, Morrell CN. Aging. 2019 December;11:11955-11974. [Full Text Article] [PubMed:31852838] [PMC:PMC6949047]

Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series. Jillian F Wise, Sigve Nakken, Chloé B Steen, Daniel Vodák, Gunhild Trøen, Bjarne Johannessen, Ole Christian Lingjærde, Vera Hilden, Yngvild Nuvin Blaker, Baoyan Bai, Lars Birger Aasheim, Annika Pasanen, Susanne Lorenz, Anita Sveen, Ragnhild A Lothe, Ola Myklebost, Sirpa Leppä, Leonardo A Meza-Zepeda, Klaus Beiske, Michael S Lawrence, Eivind Hovig, June Helen Myklebust, Erlend B Smeland, Harald Holte. Blood Advances. 2020 May;4:1859-1866. [Full Text Article] [PubMed:32374878] [PMC:PMC7218413] Related Antibodies: LS-B2200.

Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker10<sup> The Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester, UK. sm460@le.ac.uk. Marta Poblocka, Akang Leonard Bassey , Victoria M Smith, Marta Falcicchio , Ana Sousa Manso, Mohammad Althubiti , XiaoBo Sheng, Andrew Kyle, Ruth Barber, Mark Frigerio, Salvador Macip. Scientific reports. 2021 Oct;11:20358. [Full Text Article] [PubMed:34645909] [PMC:PMC8514501] Related Antibodies: LS-B2200.

ß2<sub>-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression. Daniel Hofbauer, Dimitrios Mougiakakos, Luca Broggini, Mario Zaiss, Maike Büttner-Herold, Christian Bach, Bernd Spriewald, Frank Neumann, Savita Bisht, Jens Nolting, Robert Zeiser, Shaima'a Hamarsheh, Martin Eberhardt, Julio Vera, Cristina Visentin, Chiara Maria Giulia De Luca, Fabio Moda, Stefan Haskamp, Cindy Flamann, Martin Böttcher, Katrin Bitterer, Simon Völkl, Andreas Mackensen, Stefano Ricagno, Heiko Bruns. Immunity. 2021 August;54:1772-1787e9. [Full Text Article] [PubMed:34289378] Related Antibodies: LS-B2200.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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