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AZU1 / Azurocidin

azurocidin 1

This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.

Gene Name: azurocidin 1
Family/Subfamily: Protease , Serine S1
Synonyms: AZU1, AZU, AZAMP, Azurocidin, CAP37, HUMAZUR, HBP, NAZC, Neutrophil azurocidin, Azurocidin 1
Target Sequences: NM_001700 NP_001691.1 P20160

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Products
Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
AZU1 / Azurocidin (6)
No (6)
6His, C-terminus (2)
GST (1)
His (1)
Myc-DDK (Flag) (2)
Human (5)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (2)
AZU1 / Azurocidin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
26.89 kDa
100 µg/$494
AZU1 / Azurocidin Protein - 12.5% SDS-PAGE of human AZU1 stained with Coomassie Blue
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Wheat Germ Extract
GST
53.3 kDa
2 µg/$439
AZU1 / Azurocidin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
26.89 kDa
20 µg/$150
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.24kD
10 µg/$269; 50 µg/$372; 500 µg/$1,585; 1 mg/$2,157
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Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.2 kDa
10 µg/$269; 50 µg/$368
AZU1 / Azurocidin Protein - Recombinant Azurocidin 1 By SDS-PAGE
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E. coli
His
25.9 kDa
10 µg/$273; 50 µg/$390; 100 µg/$622; 200 µg/$777; 1 mg/$1,840; 500 µg/$1,398; 5 mg/$2,801; 2 mg/$2,023
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).