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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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AXL

AXL receptor tyrosine kinase

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.

Gene Name: AXL receptor tyrosine kinase
Family/Subfamily: Protein Kinase , Axl
Synonyms: AXL, AXL transforming sequence/gene, Oncogene AXL, AXL oncogene, AXL receptor tyrosine kinase, JTK11, Tyro7, UFO
Target Sequences: NM_001699 NP_001690.2 P30530

Filtered By: None
Type
Custom (2)
Sandwich (9)
Target
AXL (11)
Reactivity
Human (6)
Mouse (4)
Rat (1)
Sample Type
Cell Culture Supernatants (6)
Plasma (9)
Serum (9)
Tissue Homogenates (2)
Showing 1-11 of 11 results

Human AXL ELISA Kit (Sandwich ELISA) - LS-F2608
Sandwich
96-Well Microplate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1plate  $530.00
LSBio image for ELISA Kit
LSBio image for ELISA Kit

Human AXL ELISA Kit (Sandwich ELISA) - LS-F33
Sandwich
96-Well Microplate
Human
2.743 - 666.7 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1plate  $470.00
LSBio image for ELISA Kit
LSBio image for ELISA Kit

Mouse AXL ELISA Kit (Sandwich ELISA) - LS-F219
Sandwich
96-Well Microplate
Mouse
1.024 - 100 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1plate  $470.00
LSBio image for ELISA Kit
LSBio image for ELISA Kit

Mouse AXL ELISA Kit (Sandwich ELISA) - LS-F2609
Sandwich
96-Well Microplate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1plate  $530.00
LSBio image for ELISA Kit
LSBio image for ELISA Kit

Rat AXL ELISA Kit (Sandwich ELISA) - LS-F9791
Sandwich
96-Well Strip Plate
Rat
2.34 - 150 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate  $940.00
LSBio image for ELISA Kit
LSBio image for ELISA Kit

Human AXL ELISA Kit (Custom ELISA) - LS-F19763
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1plate  $650.00
LSBio image for ELISA Kit
LSBio image for ELISA Kit

Mouse AXL ELISA Kit (Custom ELISA) - LS-F19762
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1plate  $650.00
LSBio image for ELISA Kit
LSBio image for ELISA Kit

Mouse AXL ELISA Kit (Sandwich ELISA) - LS-F24713
Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1plate  $550.00
LSBio image for ELISA Kit
LSBio image for ELISA Kit

Human AXL ELISA Kit (Sandwich ELISA) - LS-F24357
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1plate  $550.00
LSBio image for ELISA Kit
LSBio image for ELISA Kit

Human AXL ELISA Kit (Sandwich ELISA) - LS-F39101
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate  $720.00
LSBio image for ELISA Kit
LSBio image for ELISA Kit

Human AXL ELISA Kit (Sandwich ELISA) - LS-F54673
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate  $870.00
LSBio image for ELISA Kit
LSBio image for ELISA Kit
Showing 1-11 of 11 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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