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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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AXL

AXL receptor tyrosine kinase

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.

Gene Name: AXL receptor tyrosine kinase
Family/Subfamily: Protein Kinase , Axl
Synonyms: AXL, AXL transforming sequence/gene, Oncogene AXL, AXL oncogene, AXL receptor tyrosine kinase, JTK11, Tyro7, UFO
Target Sequences: NM_001699 NP_001690.2 P30530

Filtered By: None
Target
AXL (65)
Reactivity
Human (49)
Mouse (16)
Rat (19)
Bovine (3)
Dog (4)
Guinea pig (3)
Horse (1)
Monkey (4)
Pig (3)
Rabbit (1)
Application
IHC (34)
IHC-P (10)
WB (60)
Flo (11)
ELISA (28)
ICC (2)
IF (1)
IP (2)
Peptide-ELISA (2)
RNAi (1)
Host
rabbit (62)
mouse (3)
Isotype
IgG (49)
IgG1 (2)
IgG2a,k (1)
Clonality
monoclonal mc (3)
polyclonal pc (62)
Clone
1B3A2 (1)
6C8 (1)
7E10 (1)
Format
AP Conjugated (4)
APC (1)
APC Conjugated (5)
Azide-free (3)
Biotin Conjugated (8)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (8)
HRP Conjugated (7)
PE Conjugated (5)
Unconjugated (26)
Epitope
aa21-202 (10)
aa122-149 (8)
aa13-44 (8)
aa863-894 (8)
C-Terminus (5)
640-720 aa (1)
N-Terminus (1)
aa250-300 (1)
aa838-872 (1)
aa844-894 (1)
pTyr691 (1)
pTyr697 (1)
pTyr703 (1)
Publications
No (65)
Showing 1-25 of 65 results

AXL Antibody (clone 7E10) IHC-plus™ LS-B6124
Mouse Monoclonal [clone 7E10] (IgG1) to Human AXL
Human
ELISA IF IHC IHC-P WB
Unconjugated
50µl  $425.00
Anti-AXL antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Anti-AXL antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Anti-AXL antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Anti-AXL antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.

AXL Antibody (aa13-44) LS-C100246
Rabbit Polyclonal to Human AXL
Human
Flo IHC IHC-P WB
Unconjugated
400µl  $305.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of anti-AXL N-term antibody in SKBR3 cell lysate. AXL (arrow) was detected using purified antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of anti-AXL N-term antibody in SKBR3 cell lysate. AXL (arrow) was detected using purified antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

AXL Antibody (aa122-149, Biotin) LS-C252177
Rabbit Polyclonal (IgG) to Mouse AXL
Mouse
ELISA WB
Biotin Conjugated
200µl 0.5mg/ml  $680.00

AXL Antibody (aa122-149, PE) LS-C252180
Rabbit Polyclonal (IgG) to Mouse AXL
Mouse
ELISA WB
PE Conjugated
200µl 0.6mg/ml  $680.00

AXL Antibody (C-Terminus) IHC-plus™ LS-B12012
Rabbit Polyclonal to Human AXL
Human, Monkey
IHC IHC-P WB
Unconjugated
50µg  $485.00
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.

AXL Antibody (aa863-894) LS-C100247
Rabbit Polyclonal to Human AXL
Human
IHC IHC-P WB
Unconjugated
400µl  $305.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of anti-AXL C-term antibody in SKBR3 cell lysate. AXL (arrow) was detected using purified antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of anti-AXL C-term antibody in SKBR3 cell lysate. AXL (arrow) was detected using purified antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

AXL Antibody (640-720 aa) LS-C382231
Rabbit Polyclonal (IgG) to Human AXL
Mouse, Rat, Human
ELISA IHC
Unconjugated
100µl 1mg/ml  $265.00

AXL Antibody (aa13-44) LS-C319733
Rabbit Polyclonal (IgG) to Human AXL
Human
ELISA Flo IHC WB
Unconjugated
200µl  $530.00

AXL Antibody (aa13-44, Biotin) LS-C252183
Rabbit Polyclonal (IgG) to Human AXL
Human
ELISA Flo IHC WB
Biotin Conjugated
200µl  $680.00

AXL Antibody (aa13-44, FITC) LS-C252184
Rabbit Polyclonal (IgG) to Human AXL
Human
ELISA Flo IHC WB
FITC Conjugated
200µl  $680.00

AXL Antibody (aa13-44, AP) LS-C252181
Rabbit Polyclonal (IgG) to Human AXL
Human
ELISA Flo IHC WB
AP Conjugated
200µl  $680.00

AXL Antibody (aa13-44, APC) LS-C252182
Rabbit Polyclonal (IgG) to Human AXL
Human
ELISA Flo IHC WB
APC Conjugated
200µl 0.5mg/ml  $680.00

AXL Antibody (aa13-44, Azide-free, HRP) LS-C252185
Rabbit Polyclonal (IgG) to Human AXL
Human
ELISA Flo IHC WB
HRP Conjugated, Azide-free
200µl  $680.00

AXL Antibody (aa13-44, PE) LS-C252186
Rabbit Polyclonal (IgG) to Human AXL
Human
ELISA Flo IHC WB
PE Conjugated
200µl  $680.00

AXL Antibody LS-C100248
Rabbit Polyclonal to Human AXL
Human
Flo IHC IHC-P WB
Unconjugated
400µl  $305.00
Formalin-fixed and paraffin-embedded human colon carcinoma with AXL Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of anti-AXL Antibody in A375 cell line lysates (35 ug/lane). AXL(arrow) was detected using the purified antibody.
Formalin-fixed and paraffin-embedded human colon carcinoma with AXL Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of anti-AXL Antibody in A375 cell line lysates (35 ug/lane). AXL(arrow) was detected using the purified antibody.

AXL Antibody LS-C659469
Rabbit Polyclonal (IgG) to Human AXL
Human
ELISA Flo IP WB
Unconjugated
100µg  $405.00

AXL Antibody (phospho-Tyr691) LS-C198665
Rabbit Polyclonal (IgG) to Human AXL
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human brain, using AXL (Phospho-Tyr691) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from HUVEC cells treated with EGF 200ng/ml 15', using AXL (Phospho-Tyr691) Antibody. The lane on the right is blocked with the phospho peptide.
Immunohistochemistry analysis of paraffin-embedded human brain, using AXL (Phospho-Tyr691) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from HUVEC cells treated with EGF 200ng/ml 15', using AXL (Phospho-Tyr691) Antibody. The lane on the right is blocked with the phospho peptide.

AXL Antibody LS-C330992
Rabbit Polyclonal (IgG) to Human AXL
Human
Flo IHC WB
Unconjugated
50µl  $305.00
Western blot analysis of extracts of HepG2 cells, using AXL antibody. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.
Western blot analysis of extracts of HepG2 cells, using AXL antibody. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.

AXL Antibody (clone 6C8) LS-C196729
Mouse Monoclonal [clone 6C8] (IgG2a,k) to Human AXL
Human
ELISA RNAi WB
Unconjugated
100µg  $355.00
AXL monoclonal antibody (M01), clone 6C8 Western Blot analysis of AXL expression in HeLa.
Western Blot analysis of AXL expression in transfected 293T cell line by AXL monoclonal antibody (M01), clone 6C8.Lane 1: AXL transfected lysate(98 KDa).Lane 2: Non-transfected lysate.
AXL monoclonal antibody (M01), clone 6C8 Western Blot analysis of AXL expression in HeLa.
Western Blot analysis of AXL expression in transfected 293T cell line by AXL monoclonal antibody (M01), clone 6C8.Lane 1: AXL transfected lysate(98 KDa).Lane 2: Non-transfected lysate.

AXL Antibody (aa863-894) LS-C326900
Rabbit Polyclonal (IgG) to Human AXL
Human
ELISA IHC WB
Unconjugated
200µl 0.25mg/ml  $530.00

AXL Antibody (aa863-894, Biotin) LS-C275343
Rabbit Polyclonal (IgG) to Human AXL
Human
ELISA IHC WB
Biotin Conjugated
200µl  $680.00

AXL Antibody (aa863-894, Azide-free, HRP) LS-C275346
Rabbit Polyclonal (IgG) to Human AXL
Human
ELISA IHC WB
HRP Conjugated, Azide-free
200µl  $680.00

AXL Antibody (aa863-894, APC) LS-C275344
Rabbit Polyclonal (IgG) to Human AXL
Human
ELISA IHC WB
APC Conjugated
200µl  $680.00

AXL Antibody (aa863-894, PE) LS-C275347
Rabbit Polyclonal (IgG) to Human AXL
Human
ELISA IHC WB
PE Conjugated
200µl  $680.00

AXL Antibody LS-C671320
Rabbit Polyclonal (IgG) to Human AXL
Human
ELISA IHC IHC-P
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Showing 1-25 of 65 results

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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