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AVP / ADH / Vasopressin

arginine vasopressin

AVP / ADH / Vasopressin is a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI).

Gene Name: arginine vasopressin
Family/Subfamily: Ligand , not assigned-Ligand
Synonyms: AVP, ADH, Antidiuretic hormone, ARVP, Vasopressin, Neurohypophyseal, Arginine vasopressin, AVP-NPII, AVRP, VP
Target Sequences: NM_000490 NP_000481.2 P01185

Publications (1)

1
Dietary Essential Amino Acid Restriction Promotes Hyperdipsia via Hepatic FGF21. Patricia M Rusu, Andrea Y Chan, Mathias Heikenwalder, Oliver J Müller, Adam J Rose. Nutrients. 2021 April;13: [Full Text Article] [PubMed:33926065] [PMC:PMC8144947]

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
AVP / ADH / Vasopressin (4)
No (4)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
AVP / ADH / Vasopressin Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
AVP / ADH / Vasopressin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
17.32 kDa
100 µg/$494
AVP / ADH / Vasopressin Protein - Purified recombinant protein AVP was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
15.3 kDa
20 µg/$1,107
AVP / ADH / Vasopressin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
17.32 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).