Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
|Gene Name:||autophagy related 4C, cysteine peptidase|
|Synonyms:||ATG4C, AUTL3, APG4-C, APG4C, AUTL1, Autophagin-3, APG4 autophagy 4 homolog C, Cysteine protease ATG4C|
|Target Sequences:||NM_032852 NP_116241.2 Q96DT6|
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