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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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AUTL1 / ATG4C

autophagy related 4C, cysteine peptidase

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Gene Name: autophagy related 4C, cysteine peptidase
Synonyms: ATG4C, AUTL3, APG4-C, APG4C, AUTL1, Autophagin-3, APG4 autophagy 4 homolog C, Cysteine protease ATG4C
Target Sequences: NM_032852 NP_116241.2 Q96DT6

Publications (1)

1
Temporal orchestration of circadian autophagy rhythm by C/EBP. Ma D, Panda S, Lin JD. The EMBO journal. 2011 30:4642-51. [PubMed:21897364] [PMC:PMC3243590] Related Antibodies: LS-C156598.


AUTL1 / ATG4C Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal (IgG) to Human AUTL1 / ATG4C
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
AUTL1 / ATG4C Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Select
Rabbit Polyclonal to Human AUTL1 / ATG4C
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
AUTL1 / ATG4C Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Select
Rabbit Polyclonal to Human AUTL1 / ATG4C
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Sheep Polyclonal (IgG) to Human AUTL1 / ATG4C
Mouse, Rat, Human
IHC, WB
Unconjugated
500µg   $325.00
AUTL1 / ATG4C Antibody - Immunohistochemical analysis of ATG4C staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX. w
Select
Rabbit Polyclonal to Human AUTL1 / ATG4C
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $245.00
AUTL1 / ATG4C Antibody - 1:100 staining mouse muscle tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human AUTL1 / ATG4C
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
AUTL1 / ATG4C Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using ATG4C antibody.
Select
Rabbit Polyclonal (IgG) to Human AUTL1 / ATG4C
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $305.00
AUTL1 / ATG4C Antibody - Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using ATG4C Antibody. The picture on the right is blocked with the synthesized peptide.
Select
Rabbit Polyclonal (IgG) to Human AUTL1 / ATG4C
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
Select
Rabbit Polyclonal (IgG) to Human AUTL1 / ATG4C
Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human AUTL1 / ATG4C
Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $405.00
AUTL1 / ATG4C Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
Select
Rabbit Polyclonal (IgG) to Human AUTL1 / ATG4C
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   $285.00; 100µl   $385.00
AUTL1 / ATG4C Antibody - Immunohistochemistry of paraffin-embedded human testis tissue using ATG4C Antibody at dilution of 1:100
Select
Rabbit Polyclonal (IgG) to Human AUTL1 / ATG4C
Human
ELISA, IF, IHC
Unconjugated
50µg   $285.00; 100µg   $385.00
AUTL1 / ATG4C Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Select
Rabbit Polyclonal to Human AUTL1 / ATG4C
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
AUTL1 / ATG4C Antibody - Western blot analysis using ATG4C mAb against HEK293 (1) and ATG4C (AA: 321-458)-hIgGFc transfected HEK293 (2) cell lysate.
Select
Mouse Monoclonal [clone 2E10H7] (IgG1) to Human AUTL1 / ATG4C
Human
ELISA, WB
Unconjugated
100µl   $365.00
AUTL1 / ATG4C Antibody - Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-ATG4C Polyclonal Antibody. Tissue: Myoblast cell line (C2C12). Species: Mouse. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-ATG4C Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ATG4C Antibody (D) Composite.
Select
Rabbit Polyclonal to Human AUTL1 / ATG4C
Mouse, Rat, Human
IF, WB
Unconjugated
100µg   1mg/ml   $365.00
Select
Mouse Monoclonal [clone 287CT12.2.2] (IgG1,k) to Mouse AUTL1 / ATG4C
Mouse
ELISA, WB
Unconjugated
200µl   $590.00
AUTL1 / ATG4C Antibody - Western blot of testis cell lysate, using ATG4C antibody.
Select
Rabbit Polyclonal to Human AUTL1 / ATG4C
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl   $385.00
AUTL1 / ATG4C Antibody - Western blot analysis of extracts of various cell lines.
Select
Rabbit Polyclonal (IgG) to Human AUTL1 / ATG4C
Human
IHC, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $315.00; 200µl   $425.00
AUTL1 / ATG4C Antibody - Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-ATG4C Polyclonal Antibody. Tissue: Colon carcinoma cell line (RKO). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-ATG4C Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) ATG4C Antibody. (D) Composite.
Select
Rabbit Polyclonal to Human AUTL1 / ATG4C
Human
IF, WB
Unconjugated
100µg   1mg/ml   $365.00
AUTL1 / ATG4C Antibody - Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-ATG4C Polyclonal Antibody. Tissue: Myoblast cell line (C2C12). Species: Mouse. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-ATG4C Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ATG4C Antibody (D) Composite.
Select
Rabbit Polyclonal to Human AUTL1 / ATG4C
Mouse, Rat, Human
IF, WB
Biotin Conjugated
100µg   1mg/ml   $395.00
AUTL1 / ATG4C Antibody - Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-ATG4C Polyclonal Antibody. Tissue: Myoblast cell line (C2C12). Species: Mouse. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-ATG4C Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ATG4C Antibody (D) Composite.
Select
Rabbit Polyclonal to Human AUTL1 / ATG4C
Mouse, Rat, Human
IF, WB
Atto 565 Conjugated
100µg   1mg/ml   $395.00
AUTL1 / ATG4C Antibody - Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-ATG4C Polyclonal Antibody. Tissue: Myoblast cell line (C2C12). Species: Mouse. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-ATG4C Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ATG4C Antibody (D) Composite.
Select
Rabbit Polyclonal to Human AUTL1 / ATG4C
Mouse, Rat, Human
IF, WB
Atto 594 Conjugated
100µg   1mg/ml   $395.00
AUTL1 / ATG4C Antibody - Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-ATG4C Polyclonal Antibody. Tissue: Myoblast cell line (C2C12). Species: Mouse. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-ATG4C Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ATG4C Antibody (D) Composite.
Select
Rabbit Polyclonal to Human AUTL1 / ATG4C
Mouse, Rat, Human
IF, WB
APC Conjugated
100µg   1mg/ml   $395.00
AUTL1 / ATG4C Antibody - Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-ATG4C Polyclonal Antibody. Tissue: Myoblast cell line (C2C12). Species: Mouse. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-ATG4C Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ATG4C Antibody (D) Composite.
Select
Rabbit Polyclonal to Human AUTL1 / ATG4C
Mouse, Rat, Human
IF, WB
AP Conjugated
100µg   1mg/ml   $395.00
AUTL1 / ATG4C Antibody - Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-ATG4C Polyclonal Antibody. Tissue: Myoblast cell line (C2C12). Species: Mouse. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-ATG4C Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ATG4C Antibody (D) Composite.
Select
Rabbit Polyclonal to Human AUTL1 / ATG4C
Mouse, Rat, Human
IF, WB
RPE Conjugated
100µg   1mg/ml   $395.00
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).