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Unfortunately, the antibody (ID:47445) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



AURKA / Aurora-A

aurora kinase A

Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.

Gene Name: aurora kinase A
Family/Subfamily: Protein Kinase , Aurora/IPL1-like
Synonyms: AURKA, AIK, AIRK1, ARK1, Aurora-A kinase, Aurora kinase A, Aurora/IPL1-like kinase, AYK1, AURA, AURORA2, Breast tumor-amplified kinase, Breast-tumor-amplified kinase, BTAK, HARK1, IPL1-related kinase, Serine/threonine kinase 6, STK7, STK6, PPP1R47, ARK-1, Aurora 2, Aurora-A, Aurora-related kinase 1, Aurora/IPL1-related kinase 1, IAK1, Serine/threonine kinase 15, STK15
Target Sequences: NM_003600 NP_003591.2 O14965

Publications (4)

1
Specialized roles of the two mitotic cyclins in somatic cells: cyclin A as an activator of M phase-promoting factor. Fung TK, Ma HT, Poon RY. Molecular biology of the cell. 2007 18:1861-73. [PubMed:17344473] [PMC:PMC1855023] Related Antibodies: LS-C41212.
2
Cotreatment with vorinostat enhances activity of MK-0457 (VX-680) against acute and chronic myelogenous leukemia cells. Fiskus W, Wang Y, Joshi R, Rao R, Yang Y, Chen J, Kolhe R, Balusu R, Eaton K, Lee P, Ustun C, Jillella A, Buser CA, Peiper S, Bhalla K. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008 14:6106-15. (WB) [PubMed:18829489] [PMC:PMC2665710]
3
Curcumin-induced mitotic spindle defect and cell cycle arrest in human bladder cancer cells occurs partly through inhibition of aurora A. Liu HS, Ke CS, Cheng HC, Huang CY, Su CL. Molecular pharmacology. 2011 80:638-46. [PubMed:21757545]
4
Expression of aurora kinase A and B in chondrosarcoma and its relationship with the prognosis. Liang X, Wang D, Wang Y, Zhou Z, Zhang J, Li J. Diagnostic pathology. 2012 7:84. [PubMed:22809428] [PMC:PMC3487823]
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Filtered By: None
Target
aurka-aurora-a (80)
Reactivity
Human (69)
Mouse (36)
Rat (23)
Bovine (9)
Chimpanzee (6)
Dog (4)
Gibbon (3)
Guinea pig (4)
Horse (4)
Monkey (9)
Orangutan (3)
Pig (2)
Primate (1)
Rabbit (4)
Sheep (9)
Zebrafish (4)
Application
IHC (18)
IHC-Fr (2)
IHC-P (17)
WB (66)
Flo (3)
ELISA (31)
ICC (10)
IF (17)
IP (12)
Host
rabbit (68)
mouse (11)
goat (1)
Isotype
IgG (40)
IgG1 (3)
IgG1,k (2)
IgG2a,k (1)
IgG2b (2)
IgM (1)
Clonality
monoclonal mc (11)
polyclonal pc (69)
Clone
1364CT291.108.155 (1)
1F8 (2)
3H1 (1)
4G10 (1)
5F8 (1)
7A3 (1)
Format
Agarose Conjugated (3)
AP Conjugated (2)
APC Conjugated (2)
Azide-free (2)
Biotin Conjugated (5)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (58)
Epitope
N-Terminus (12)
pThr288 (10)
C-Terminus (7)
aa92-120 (7)
aa151-200 (4)
aa75-125 (3)
aa50-100 (2)
pSer342 (2)
Pro282 (1)
Tyr338 (1)
aa100-150 (1)
aa109-125 (1)
aa230-310 (1)
aa256-305 (1)
aa280-360 (1)
aa311-360 (1)
aa394-403 (1)
aa90-120 (1)
aa93-120 (1)
pSer241 (1)
Publications
No (79)
Yes (1)
Showing 1-25 out of 80 results
Anti-AURKA / Aurora-A Antibody (aa394-403) IHC-plus™ LS-B191

Goat Polyclonal to Human AURKA / Aurora-A
Human
ELISA IHC-P IP WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (N-Terminus) LS-C41212

Rabbit Polyclonal (IgG) to Mouse AURKA / Aurora-A
Mouse, Human
IF WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (aa100-150) IHC-plus™ LS-B6517

Rabbit Polyclonal to Human AURKA / Aurora-A
Mouse, Rat, Human
IHC-P WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (clone 7A3) IHC-plus™ LS-B3912

Mouse Monoclonal [clone 7A3] (IgM) to Human AURKA / Aurora-A
Human
IF IHC-P WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (phospho-Thr288) LS-C205304

Rabbit Polyclonal to Human AURKA / Aurora-A
Mouse, Human
IHC-P
Unconjugated
Anti-AURKA / Aurora-A Antibody (clone 1F8) LS-C169310

Mouse Monoclonal [clone 1F8] (IgG1) to Human AURKA / Aurora-A
Rat, Human, Monkey
ELISA Flo ICC IF IHC WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (clone 1F8) LS-C359318

Mouse Monoclonal [clone 1F8] (IgG1) to Human AURKA / Aurora-A
Rat, Primate, Human
ELISA Flo ICC IF WB
Unconjugated
Anti-AURKA / Aurora-A Antibody LS-C137035

Rabbit Polyclonal (IgG) to Human AURKA / Aurora-A
Human
ELISA WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (C-Terminus) LS-C354094

Rabbit Polyclonal to Human AURKA / Aurora-A
Mouse, Rat, Pig, Human, Monkey
ICC IF IHC-P WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (aa280-360) LS-C382140

Rabbit Polyclonal (IgG) to Human AURKA / Aurora-A
Mouse, Rat, Human, Monkey
ELISA IF IHC WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (phospho-Thr288) LS-C358422

Rabbit Polyclonal to Human AURKA / Aurora-A
Mouse, Sheep, Bovine, Rat, Pig, Human, Monkey
ICC IF IHC-P WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (C-Terminus) IHC-plus™ LS-B6732

Rabbit Polyclonal (IgG) to Human AURKA / Aurora-A
Sheep, Bovine, Human
IHC-P WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (clone 5F8) LS-C133953

Mouse Monoclonal [clone 5F8] (IgG2a,k) to Human AURKA / Aurora-A
Human
ELISA IF WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (C-Terminus) LS-C287011

Rabbit Polyclonal (IgG) to Mouse AURKA / Aurora-A
Mouse, Rat
ICC IF WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (clone 3H1) LS-C204509

Mouse Monoclonal [clone 3H1] (IgG1,k) to Human AURKA / Aurora-A
Human
ICC IF WB
Unconjugated
Anti-AURKA / Aurora-A Antibody LS-C497939

Rabbit Polyclonal (IgG) to Human AURKA / Aurora-A
Human
Flo IF WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (N-Terminus) LS-C326899

Rabbit Polyclonal (IgG) to Human AURKA / Aurora-A
Human
ELISA IHC WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (N-Terminus, AP) LS-C218676

Rabbit Polyclonal (IgG) to Human AURKA / Aurora-A
Human
ELISA IHC WB
AP Conjugated
Anti-AURKA / Aurora-A Antibody (clone 4G10) LS-C169311

Mouse Monoclonal [clone 4G10] (IgG1) to Human AURKA / Aurora-A
Rat, Human, Monkey
ELISA IHC-P WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (phospho-Thr288) LS-C381244

Rabbit Polyclonal (IgG) to Human AURKA / Aurora-A
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (N-Terminus) LS-C44482

Mouse Monoclonal (IgG2b) to Human AURKA / Aurora-A
Mouse, Human
IF IP WB
Unconjugated
Anti-AURKA / Aurora-A Antibody LS-C83025

Rabbit Polyclonal to Human AURKA / Aurora-A
Human
IF IP WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (Tyr338) LS-C176675

Rabbit Polyclonal to Human AURKA / Aurora-A
Mouse, Rat, Human
IF IHC-P WB
Unconjugated
Anti-AURKA / Aurora-A Antibody (phospho-Thr288) LS-C286340

Rabbit Polyclonal (IgG) to Human AURKA / Aurora-A
Human
ICC IF
Unconjugated
Anti-AURKA / Aurora-A Antibody (aa75-125) LS-C286339

Rabbit Polyclonal (IgG) to Human AURKA / Aurora-A
Human
ICC IF
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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