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ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
ATP6AP1 is a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development.
| Gene Name: | ATPase, H+ transporting, lysosomal accessory protein 1 |
| Family/Subfamily: | Transporter , ATPase - V type |
| Synonyms: | ATP6AP1, 16A, ATP6IP1, ATP6S1, Ac45, H-ATPase subunit, ORF, V-ATPase subunit S1, VATPS1, XAP-3, Protein XAP-3, V-ATPase Ac45 subunit, V-ATPase S1 subunit, CF2, V-ATPase S1 accessory protein, XAP3 |
| Target Sequences: | NM_001183 NP_001174.2 |
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