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ATP2B2 / PMCA2

ATPase, Ca++ transporting, plasma membrane 2

ATP2B2 / PMCA2 belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Name: ATPase, Ca++ transporting, plasma membrane 2
Family/Subfamily: Transporter , ATPase - P type, type IIB
Synonyms: ATP2B2, PMCA2, Plasma membrane calcium ATPase, PMCA2i, Plasma membrane Ca2+ pump 2, Plasma membrane calcium pump, Plasma membrane Ca(2+)-ATPase, PMCA2a
Target Sequences: NM_001683 NP_001674.2 Q01814

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
ATP2B2 / PMCA2 (4)
No (4)
His-GST-S (1)
Myc-DDK (Flag) (3)
Human (2)
Mouse (1)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
ATP2B2 / PMCA2 Protein - Recombinant  ATPase, Ca++ Transporting, Plasma Membrane 2 By SDS-PAGE
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E. coli
His-GST-S
75.8 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
ATP2B2 / PMCA2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
136.7 kDa
100 µg/$710
ATP2B2 / PMCA2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
136.7 kDa
20 µg/$215
ATP2B2 / PMCA2 Protein - Purified recombinant protein ATP2B2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
136.7 kDa
20 µg/$1,107
Viewing 1-4 of 4 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).