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ATP1B1

ATPase, Na+/K+ transporting, beta 1 polypeptide

ATP1B1 belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.

Gene Name: ATPase, Na+/K+ transporting, beta 1 polypeptide
Family/Subfamily: Transporter , ATPase - P type, beta subunit
Synonyms: ATP1B1, Adenosinetriphosphatase, ATP1B, Atpb1
Target Sequences: NM_001677 NP_001668.1 P05026

Publications (8)

1
The H,K-ATPase beta subunit as a model to study the role of N-glycosylation in membrane trafficking and apical sorting. Vagin O, Turdikulova S, Sachs G. The Journal of biological chemistry. 2004 279:39026-34. [PubMed:15247221]
2
Use of the H,K-ATPase beta subunit to identify multiple sorting pathways for plasma membrane delivery in polarized cells. Vagin O, Turdikulova S, Yakubov I, Sachs G. The Journal of biological chemistry. 2005 280:14741-54. (WB; Dog) [PubMed:15695513]
3
Recombinant addition of N-glycosylation sites to the basolateral Na,K-ATPase beta1 subunit results in its clustering in caveolae and apical sorting in HGT-1 cells. Vagin O, Turdikulova S, Sachs G. The Journal of biological chemistry. 2005 280:43159-67. [PubMed:16230337]
4
The C-terminal flavin domain of gp91phox bound to plasma membranes of granulocyte-like X-CGD PLB-985 cells is sufficient to anchor cytosolic oxidase components and support NADPH oxidase-associated diaphorase activity independent of cytosolic phospholipase. Pessach I, Shmelzer Z, Leto TL, Dinauer MC, Levy R. Journal of leukocyte biology. 2006 80:630-9. [PubMed:16844764]
5
Distinct endocytic recycling of myelin proteins promotes oligodendroglial membrane remodeling. Winterstein C, Trotter J, Krmer-Albers EM. Journal of cell science. 2008 121:834-42. [PubMed:18303048]
6
Expression of H(+),K(+)-ATPase and glycopattern analysis in the gastric glands of Rana esculenta. Mastrodonato M, Calamita G, Rossi R, Scillitani G, Liquori GE, Ferri D. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2009 57:215-25. [PubMed:19001639] [PMC:PMC2664934]
7
Identification of the amino acid region involved in the intercellular interaction between the 1 subunits of Na+/K+ -ATPase. Tokhtaeva E, Sachs G, Sun H, Dada LA, Sznajder JI, Vagin O. Journal of cell science. 2012 125:1605-16. (WB; Dog, Rat) [PubMed:22328500] [PMC:PMC3336383]
8
Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy. Afshari NA, Igo RP Jr, Morris NJ, Stambolian D, Sharma S, Pulagam VL, Dunn S, Stamler JF, Truitt BJ, Rimmler J, Kuot A, Croasdale CR, Qin X, Burdon KP, Riazuddin SA, Mills R, Klebe S, Minear MA, Zhao J, Balajonda E, Rosenwasser GO, Baratz KH, Mootha VV, Patel SV, Gregory SG, Bailey-Wilson JE, Price MO, Price FW Jr, Craig JE, Fingert JH, Gottsch JD, Aldave AJ, Klintworth GK, Lass JH, Li YJ, Iyengar SK. Nature communications. 2017 8:14898. (IHC; Human) [Full Text Article] [PubMed:28358029] [PMC:PMC5379100] Related Antibodies: LS-B235.
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Proteins (8)
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ATP1B1 (8)
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His (2)
Myc-DDK (Flag) (5)
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Mouse (1)
293T Cells (3)
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HEK 293 Cells (2)
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Purified (2)
ATP1B1 Protein - Recombinant ATPase, Na+/K+ Transporting Beta 1 Polypeptide By SDS-PAGE
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E. coli
His
30.7 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
ATP1B1 Protein - 12.5% SDS-PAGE of human ATP1B1 stained with Coomassie Blue
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Wheat Germ Extract
GST
58.96 kDa
2 µg/$439
ATP1B1 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
ATP1B1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
34.7 kDa
20 µg/$150
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293T Cells
Myc-DDK (Flag)
34.9 kDa
20 µg/$150
ATP1B1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
34.9 kDa
20 µg/$150
ATP1B1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
34.7 kDa
100 µg/$494
ATP1B1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
34.9 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).