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ATG3

autophagy related 3

E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Gene Name: autophagy related 3
Synonyms: ATG3, APG3-LIKE, APG3, APG3L, Autophagy related 3, HApg3, PC3-96, Protein PC3-96, Autophagy-related protein 3
Target Sequences: NM_022488 NP_071933.2 Q9NT62

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Proteins (10)
Over-Expression Lysate (2)
Recombinant (8)
ATG3 (10)
No (10)
6His, C-terminus (1)
GST (1)
GST, N-terminus (1)
His (2)
His-SUMO (1)
Myc-DDK (Flag) (3)
T7, N-terminus + 6His, C-terminus (1)
Human (9)
293T Cells (1)
E. coli (5)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (2)
ATG3 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
ATG3 Protein - 12.5% SDS-PAGE of human ATG3 stained with Coomassie Blue
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Wheat Germ Extract
GST
62.3 kDa
10 µg/$479; 25 µg/$670
ATG3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
35.7 kDa
20 µg/$150
ATG3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
35.7 kDa
100 µg/$494
ATG3 Protein
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E. coli
His-SUMO
51.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
ATG3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ATG3 Protein - Purified recombinant protein ATG3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
35.7 kDa
20 µg/$1,107
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E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36 kDa
10 µg/$322; 50 µg/$358
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E. coli
His
~37kDa (SDS-PAGE)
50 µg/$274
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E. coli
T7, N-terminus + 6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36kD
10 µg/$233; 50 µg/$269; 500 µg/$468; 1 mg/$603
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).